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dc.contributor.authorJouffrey, Ven
dc.contributor.authorLeonard, ASen
dc.contributor.authorAhnert, Sebastianen
dc.date.accessioned2021-06-10T23:30:09Z
dc.date.available2021-06-10T23:30:09Z
dc.date.issued2021-06-23en
dc.identifier.issn2054-5703
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/323697
dc.description.abstractWe study the effects of non-determinism and gene duplication on the structure of genotype-phenotype maps by introducing a non-deterministic version of the Polyomino self-assembly model. This model has previously been used in a variety of contexts to model the assembly and evolution of protein quaternary structure. Firstly we show the limit of the current deterministic paradigm which leads to built-in anti-correlation between evolvability and robustness at the genotypic level. We develop a set of metrics to measure structural properties of genotype-phenotype maps in a non-deterministic setting and use them to evaluate the effects of gene duplication and subsequent diversification. Our generalised versions of evolvability and robustness exhibit positive correlation for a subset of genotypes. This positive correlation is only possible because non-deterministic phenotypes can contribute to both robustness and evolvability. Secondly we show that duplication increases robustness and reduces evolvability initially, but that the subsequent diversification that duplication enables has a stronger, inverse effect, greatly increasing evolvability and reducing robustness relative to their original values.
dc.format.mediumElectronicen
dc.languageengen
dc.rightsAll rights reserved
dc.rights.uri
dc.titleGene duplication and subsequent diversification strongly affect phenotypic evolvability and robustness.en
dc.typeArticle
prism.issueIdentifier6en
prism.publicationDate2021en
prism.publicationNameRoyal Society open scienceen
prism.startingPage201636
prism.volume8en
dc.identifier.doi10.17863/CAM.71154
dcterms.dateAccepted2021-02-22en
rioxxterms.versionofrecord10.1098/rsos.201636en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-06-23en
dc.contributor.orcidJouffrey, V [0000-0002-6786-1484]
dc.contributor.orcidLeonard, AS [0000-0001-8425-5630]
dc.contributor.orcidAhnert, Sebastian [0000-0003-2613-0041]
dc.identifier.eissn2054-5703
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idGatsby Charitable Foundation (GAT3395/CCD)
pubs.funder-project-idEPSRC (1805372)
pubs.funder-project-idEPSRC (1642292)
pubs.funder-project-idEPSRC (1642292)
cam.orpheus.counter3*
rioxxterms.freetoread.startdate2024-06-10


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