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dc.contributor.authorSalamone, Paula Celeste
dc.contributor.authorSedeño, Lucas
dc.contributor.authorLegaz, Agustina
dc.contributor.authorBekinschtein, Tristan
dc.contributor.authorMartorell, Miguel
dc.contributor.authorAdolfi, Federico
dc.contributor.authorFraile-Vazquez, Matías
dc.contributor.authorRodríguez Arriagada, Nicolás
dc.contributor.authorFavaloro, Liliana
dc.contributor.authorPeradejordi, Margarita
dc.contributor.authorAbsi, Daniel O
dc.contributor.authorGarcía, Adolfo M
dc.contributor.authorFavaloro, Roberto
dc.contributor.authorIbáñez, Agustín
dc.date.accessioned2021-06-18T23:30:20Z
dc.date.available2021-06-18T23:30:20Z
dc.date.issued2020
dc.identifier.issn2632-1297
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/324092
dc.description.abstractHeart-brain integration dynamics are critical for interoception (i.e. the sensing of body signals). In this unprecedented longitudinal study, we assessed neurocognitive markers of interoception in patients who underwent orthotopic heart transplants and matched healthy controls. Patients were assessed longitudinally before surgery (T1), a few months later (T2) and a year after (T3). We assessed behavioural (heartbeat detection) and electrophysiological (heartbeat evoked potential) markers of interoception. Heartbeat detection task revealed that pre-surgery (T1) interoception was similar between patients and controls. However, patients were outperformed by controls after heart transplant (T2), but no such differences were observed in the follow-up analysis (T3). Neurophysiologically, although heartbeat evoked potential analyses revealed no differences between groups before the surgery (T1), reduced amplitudes of this event-related potential were found for the patients in the two post-transplant stages (T2, T3). All these significant effects persisted after covariation with different cardiological measures. In sum, this study brings new insights into the adaptive properties of brain-heart pathways.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleDynamic neurocognitive changes in interoception after heart transplant.
dc.typeArticle
prism.issueIdentifier2
prism.publicationDate2020
prism.publicationNameBrain Commun
prism.startingPagefcaa095
prism.volume2
dc.identifier.doi10.17863/CAM.71549
dcterms.dateAccepted2020-06-18
rioxxterms.versionofrecord10.1093/braincomms/fcaa095
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-01
dc.contributor.orcidBekinschtein, Tristan [0000-0001-5501-8628]
dc.identifier.eissn2632-1297
rioxxterms.typeJournal Article/Review
cam.issuedOnline2020-07-08


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International