ARDS subphenotypes: searching for Rorschach among the roentgenograms?
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Conway Morris, A., Kohler, K., & Shankar-Hari, M. (2021). ARDS subphenotypes: searching for Rorschach among the roentgenograms?. Thorax https://doi.org/10.1136/thoraxjnl-2021-217428
In 1967, Ashbaugh and colleagues first described acute respiratory distress syndrome (ARDS) - an acute illness, characterised by tachypnoea, hypoxaemia and loss of lung compliance occurring after a variety of pulmonary and non-pulmonary insults (including trauma, acute pancreatitis, viral pneumonitis)1. This concept is retained as the ARDS illness model within the current consensus definitions, with acute defined as within 7 days of insult, and hypoxaemia categorised using partial pressure of oxygen/fraction of inspired oxygen concentration (PaO2/FiO2 ratio) into mild (<40Kpa) , moderate (13.3-26.6Kpa) and severe (<=13.3Kpa) ARDS on a positive end expiratory pressure of >5 cm water2.
MS-H is supported by the National Institute for Health Research Clinician Scientist Award (NIHR-CS-2016-16-011). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the UK National Institute for Health Research or the Department of Health. ACM is supported by an MRC Clinician Scientist Fellowship (MR/V006118/1).
External DOI: https://doi.org/10.1136/thoraxjnl-2021-217428
This record's URL: https://www.repository.cam.ac.uk/handle/1810/324175
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