Prostanoids put a brake on necroptosis in IBD.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Kaneider, Nicole C
Abstract
A form of programmed cell death, necroptosis, in intestinal epithelial cells initiates mucosal inflammation. A study now finds that prostanoid EP4 receptor signalling interferes with RIPK1/RIPK3-dependent MLKL activation, thereby inhibiting necroptosis and accelerating resolution of inflammation.
Description
Keywords
Humans, Inflammatory Bowel Diseases, Necroptosis, Prostaglandins, Receptor-Interacting Protein Serine-Threonine Kinases
Journal Title
Nat Cell Biol
Conference Name
Journal ISSN
1465-7392
1476-4679
1476-4679
Volume Title
23
Publisher
Springer Science and Business Media LLC
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Rights
All rights reserved