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dc.contributor.authorMohammad, Anwar
dc.contributor.authorZiyab, Ali H
dc.contributor.authorMohammad, Talal
dc.date.accessioned2021-06-28T00:53:33Z
dc.date.available2021-06-28T00:53:33Z
dc.date.issued2021
dc.identifier.citationDiabetes, metabolic syndrome and obesity : targets and therapy, volume 14, page 2167-2176
dc.identifier.issn1178-7007
dc.identifier.otherPMC8140943
dc.identifier.other34040403
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/324471
dc.description.abstractPurpose: This study aimed to estimate the prevalence of prediabetes and undiagnosed type 2 diabetes mellitus (T2DM) according to fasting plasma glucose (FPG), 2-h plasma glucose (PG) during oral glucose tolerance test (OGTT), and glycated hemoglobin (HbA1c) among a sample of Kuwaiti adults. In addition, associations of prediabetes and undiagnosed T2DM with sex, age, and body mass index (BMI) were assessed. Methods: A cross-sectional study enrolled 1238 subjects aged 18-65 years who reported no prior history of DM. After overnight fasting, FPG and HbA1c were measured in the total study sample, and 2-h PG during a 75-g OGTT was measured in a subsample of 155 subjects. Prediabetes and undiagnosed T2DM were defined according to the American Diabetes Association criteria. Associations were assessed using Poisson regression with robust variance estimation, and adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were estimated. Results: We enrolled a total of 618 males and 620 females, with an average age of 43.0 years. The prevalence of prediabetes was estimated to be 47.9% (588/1228) by FPG, 36.8% (57/155) by 2-h PG OGTT, and 31.0% (355/1144) by HbA1c. The prevalence of undiagnosed T2DM was 6.9% (85/1228) by FPG, 11.0% (17/155) by 2-h PG OGTT, and 4.9% (56/1144) by HbA1c. Sex-related differences in the prevalence of prediabetes and undiagnosed T2DM were observed. Prediabetes and undiagnosed T2DM prevalence estimates showed increasing trends as age and BMI increased. For instance, obese subjects compared to under/normal weight subjects had an increased HbA1c-defined prediabetes prevalence (aPR = 1.62, 95% CI: 1.21-2.16). Conclusion: Prediabetes and undiagnosed T2DM affect a considerable proportion of Kuwaiti adults, and variations across sex, age, and BMI exist. Hence, early identification and management of affected individuals may help reduce the public health burden.
dc.languageeng
dc.publisherInforma UK Limited
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1178-7007
dc.sourcenlmid: 101515585
dc.subjectDiabetes mellitus
dc.subjectPrevalence
dc.subjectKuwait
dc.subjectPrediabetes
dc.subjectUndiagnosed
dc.titlePrevalence of Prediabetes and Undiagnosed Diabetes Among Kuwaiti Adults: A Cross-Sectional Study.
dc.typeArticle
dc.date.updated2021-06-28T00:53:32Z
prism.publicationNameDiabetes Metab Syndr Obes
dc.identifier.doi10.17863/CAM.71923
dcterms.dateAccepted2021-03-09
rioxxterms.versionofrecord10.2147/DMSO.S296848
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidMohammad, Anwar [0000-0001-6318-8707]
dc.contributor.orcidZiyab, Ali H [0000-0003-3099-4424]
dc.identifier.eissn1178-7007
cam.issuedOnline2021-05


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International