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dc.contributor.authorCrush, Jos
dc.contributor.authorHussain, Ali
dc.contributor.authorSeah, KTM
dc.contributor.authorKhan, Wasim S
dc.date.accessioned2021-06-28T07:56:53Z
dc.date.available2021-06-28T07:56:53Z
dc.date.issued2021
dc.date.submitted2020-12-18
dc.identifier.issn2296-634X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/324482
dc.description.abstractBiomaterials are playing an increased role in the regeneration of damaged or absent bone tissue in the context of trauma, non-union, infection or congenital abnormality. Restoration of not only the physical scaffold that bone provides, but also of its homeostatic functions as a calcium store and hematopoietic organ are the gold standards of any regenerative procedure. Bioactive glasses are of interest as they can bond with the host bone and induce further both bone and blood vessel growth. The composition of the bioactive glasses can be manipulated to maximize both osteogenesis and angiogenesis, producing a 3D scaffolds that induce bone growth whilst also providing a structure that resists physiological stresses. As the primary endpoints of studies looking at bioactive glasses are very often the ability to form substantial and healthy tissues, this review will focus on the methods used to study and quantify osteogenesis and angiogenesis in bioactive glass experiments. These methods are manifold, and their accuracy is of great importance in identifying plausible future bioactive glasses for clinical use.
dc.languageen
dc.publisherFrontiers Media SA
dc.subjectCell and Developmental Biology
dc.subjectbioglass
dc.subjectangiogenesis
dc.subjectosteogenesis
dc.subjectbioactive glass
dc.subjectregenerative
dc.titleBioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis.
dc.typeArticle
dc.date.updated2021-06-28T07:56:52Z
prism.publicationNameFront Cell Dev Biol
prism.volume9
dc.identifier.doi10.17863/CAM.71934
dcterms.dateAccepted2021-05-19
rioxxterms.versionofrecord10.3389/fcell.2021.643781
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2296-634X
cam.issuedOnline2021-06-14


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