Repository logo
 

Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis.

Published version
Peer-reviewed

Change log

Authors

Crush, Jos 
Hussain, Ali 
Seah, KTM 
Khan, Wasim S 

Abstract

Biomaterials are playing an increased role in the regeneration of damaged or absent bone tissue in the context of trauma, non-union, infection or congenital abnormality. Restoration of not only the physical scaffold that bone provides, but also of its homeostatic functions as a calcium store and hematopoietic organ are the gold standards of any regenerative procedure. Bioactive glasses are of interest as they can bond with the host bone and induce further both bone and blood vessel growth. The composition of the bioactive glasses can be manipulated to maximize both osteogenesis and angiogenesis, producing a 3D scaffolds that induce bone growth whilst also providing a structure that resists physiological stresses. As the primary endpoints of studies looking at bioactive glasses are very often the ability to form substantial and healthy tissues, this review will focus on the methods used to study and quantify osteogenesis and angiogenesis in bioactive glass experiments. These methods are manifold, and their accuracy is of great importance in identifying plausible future bioactive glasses for clinical use.

Description

Keywords

angiogenesis, bioactive glass, bioglass, osteogenesis, regenerative

Journal Title

Front Cell Dev Biol

Conference Name

Journal ISSN

2296-634X
2296-634X

Volume Title

9

Publisher

Frontiers Media SA
Sponsorship
ARTHRITIS RESEARCH UK (21156)