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Information flow, cell types and stereotypy in a full olfactory connectome.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Bates, Alexander Shakeel  ORCID logo  https://orcid.org/0000-0002-1195-0445
Jagannathan, Sridhar R  ORCID logo  https://orcid.org/0000-0002-2078-1145
Drummond, Nikolas 

Abstract

The hemibrain connectome provides large-scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, we provide a complete description of the Drosophila olfactory system, covering all first, second and lateral horn-associated third-order neurons. We develop a generally applicable strategy to extract information flow and layered organisation from connectome graphs, mapping olfactory input to descending interneurons. This identifies a range of motifs including highly lateralised circuits in the antennal lobe and patterns of convergence downstream of the mushroom body and lateral horn. Leveraging a second data set we provide a first quantitative assessment of inter- versus intra-individual stereotypy. Comparing neurons across two brains (three hemispheres) reveals striking similarity in neuronal morphology across brains. Connectivity correlates with morphology and neurons of the same morphological type show similar connection variability within the same brain as across two brains.

Description

Keywords

D. melanogaster, Drosophila, connectomics, neuroanatomy, neuroscience, olfaction, stereotypy, synapses, Animals, Connectome, Datasets as Topic, Drosophila melanogaster, Female, Interneurons, Olfactory Pathways

Journal Title

Elife

Conference Name

Journal ISSN

2050-084X
2050-084X

Volume Title

10

Publisher

eLife Sciences Publications, Ltd

Rights

All rights reserved
Sponsorship
European Research Council (649111)
Wellcome Trust (203261/Z/16/Z)