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dc.contributor.authorMeek, Matt C
dc.contributor.authorBest, Serena
dc.contributor.authorCameron, Ruth
dc.date.accessioned2021-07-19T23:32:06Z
dc.date.available2021-07-19T23:32:06Z
dc.date.issued2021-11
dc.identifier.issn0022-2720
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/325257
dc.description.abstractMicro-CT is often used to assess the characteristics of porous structures such as tissue engineering scaffolds and trabecular bone. Prior to analysis, micro-CT images can be thresholded and filtered to remove noise. Scaffold pore size affects mechanical properties and biological cell behaviour and is a frequently assessed parameter. This paper identifies and characterizes an artefact affecting a commonly used filter which erroneously increases mean pore size. The 3D sweep despeckling filter removes all but the largest object within a volume of interest, and therefore deletes any disconnected objects located at the periphery, increasing measured mean pore size. This artefact is characterized, and effective methods to mitigate its effects are devised, involving despeckling a sufficiently large volume of interest, then reducing the volume of interest in size to remove the error prior to analysis. Techniques to effectively apply this method to other data sets are described. This method eliminates the artefact but is time-consuming and computationally expensive. Alternative, more economical filters which remove objects below a specified size are also assessed but are shown to be affected by the same artefact. These results will help to guide the implementation of future studies investigating the effects of pore size.
dc.description.sponsorshipDepartment of Materials Science and Metallurgy, University of Cambridge and EPSRC Established Career Fellowship Grant No. EP/N019938/1
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAll rights reserved
dc.titleThe effects of despeckling filters on pore size measurements in collagen scaffold micro-CT data.
dc.typeArticle
prism.publicationDate2021
prism.publicationNameJ Microsc
dc.identifier.doi10.17863/CAM.72713
dcterms.dateAccepted2021-07-15
rioxxterms.versionofrecord10.1111/jmi.13050
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-07-22
dc.contributor.orcidMeek, Matt C [0000-0001-9013-5168]
dc.contributor.orcidBest, Serena [0000-0001-7866-8607]
dc.contributor.orcidCameron, Ruth [0000-0003-1573-4923]
dc.identifier.eissn1365-2818
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/N019938/1)
cam.issuedOnline2021-08-13
cam.orpheus.successMon Aug 23 07:30:34 BST 2021 - Embargo updated
cam.orpheus.counter3
rioxxterms.freetoread.startdate2022-07-22


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