Building a stem cell-based primate uterus.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Bergmann, Sophie https://orcid.org/0000-0001-6018-2844
Schindler, Magdalena
Munger, Clara
Penfold, Christopher A https://orcid.org/0000-0001-5823-4705
Boroviak, Thorsten E https://orcid.org/0000-0001-8703-8949
Abstract
The uterus is the organ for embryo implantation and fetal development. Most current models of the uterus are centred around capturing its function during later stages of pregnancy to increase the survival in pre-term births. However, in vitro models focusing on the uterine tissue itself would allow modelling of pathologies including endometriosis and uterine cancers, and open new avenues to investigate embryo implantation and human development. Motivated by these key questions, we discuss how stem cell-based uteri may be engineered from constituent cell parts, either as advanced self-organising cultures, or by controlled assembly through microfluidic and print-based technologies.
Description
Funder: Wellcome Trust
Keywords
Journal Title
Communications biology
Conference Name
Journal ISSN
2399-3642
Volume Title
4