Advances in Applications of Metabolomics in Pluripotent Stem Cell Research.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Bhute, Vijesh J
Bao, Xiaoping
Palecek, Sean P
Abstract
Stem cells undergo extensive metabolic rewiring during reprogramming, proliferation and differentiation, and numerous studies have demonstrated a significant role of metabolism in controlling stem cell fates. Recent applications of metabolomics, the study of concentrations and fluxes of small molecules in cells, have advanced efforts to characterize and maturate stem cell fates, assess drug toxicity in stem cell tissue models, identify biomarkers, and study the effects of environment on metabolic pathways in stem cells and their progeny. Looking to the future, combining metabolomics with other -omics approaches will provide a deeper understanding of the complex regulatory mechanisms of stem cells.
Description
Keywords
0601 Biochemistry and Cell Biology, Biomedical, Basic Science, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Stem Cell Research - Embryonic - Non-Human, Stem Cell Research - Induced Pluripotent Stem Cell, Regenerative Medicine, Generic Health Relevance, 5.2 Cellular and gene therapies
Journal Title
Curr Opin Chem Eng
Conference Name
Journal ISSN
2211-3398
2211-3398
2211-3398
Volume Title
15
Publisher
Elsevier BV