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New closed-loop insulin systems.

Published version
Peer-reviewed

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Authors

Abstract

Advances in diabetes technologies have enabled the development of automated closed-loop insulin delivery systems. Several hybrid closed-loop systems have been commercialised, reflecting rapid transition of this evolving technology from research into clinical practice, where it is gradually transforming the management of type 1 diabetes in children and adults. In this review we consider the supporting evidence in terms of glucose control and quality of life for presently available closed-loop systems and those in development, including dual-hormone closed-loop systems. We also comment on alternative 'do-it-yourself' closed-loop systems. We remark on issues associated with clinical adoption of these approaches, including training provision, and consider limitations of presently available closed-loop systems and areas for future enhancements to further improve outcomes and reduce the burden of diabetes management.

Description

Keywords

Artificial pancreas, Automated insulin delivery, Hybrid closed-loop, Review, Type 1 diabetes, Adult, Blood Glucose, Blood Glucose Self-Monitoring, Child, Diabetes Mellitus, Type 1, Humans, Insulin, Insulin Infusion Systems, Inventions, Pancreas, Artificial

Journal Title

Diabetologia

Conference Name

Journal ISSN

0012-186X
1432-0428

Volume Title

64

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (100574/Z/12/Z)
European Commission Horizon 2020 (H2020) Societal Challenges (731560)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK085621)
National Institute of Diabetes and Digestive and Kidney Diseases (DP3DK112176)
NIHR Evaluation Trials and Studies Coordinating Centre (14/23/09)