New closed-loop insulin systems.
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Peer-reviewed
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Change log
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Abstract
Advances in diabetes technologies have enabled the development of automated closed-loop insulin delivery systems. Several hybrid closed-loop systems have been commercialised, reflecting rapid transition of this evolving technology from research into clinical practice, where it is gradually transforming the management of type 1 diabetes in children and adults. In this review we consider the supporting evidence in terms of glucose control and quality of life for presently available closed-loop systems and those in development, including dual-hormone closed-loop systems. We also comment on alternative 'do-it-yourself' closed-loop systems. We remark on issues associated with clinical adoption of these approaches, including training provision, and consider limitations of presently available closed-loop systems and areas for future enhancements to further improve outcomes and reduce the burden of diabetes management.
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Journal ISSN
1432-0428
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Sponsorship
European Commission Horizon 2020 (H2020) Societal Challenges (731560)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK085621)
National Institute of Diabetes and Digestive and Kidney Diseases (DP3DK112176)
NIHR Evaluation Trials and Studies Coordinating Centre (14/23/09)