Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta).
Middleton, Joseph Adam
Baker, Stuart Nicolas
Flecknell, Paul Andrew
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Bertrand, H. G. M. J., Middleton, J. A., Baker, S. N., Glover, I., & Flecknell, P. A. (2021). Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta).. Lab Anim, 55 (4), 363-366. https://doi.org/10.1177/0023677221990706
This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was stimulated, and SEPs were recorded from the motor cortex. The successive administration of three doses of alphaxalone (0.5, 1 and 2 mg/kg) induced an increase of the latency time and a decrease of the amplitude of the SEPs. However, the structure of the waveforms was conserved, and hence alphaxalone might represent a suitable general anaesthetic option in neuroscience research as well as veterinary or human medicine.
Short Report, Alphaxalone, somatosensory evoked potential, neurosurgery, primate
External DOI: https://doi.org/10.1177/0023677221990706
This record's URL: https://www.repository.cam.ac.uk/handle/1810/326685