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dc.contributor.authorBertrand, Henri Georges Michel Justin
dc.contributor.authorMiddleton, Joseph Adam
dc.contributor.authorBaker, Stuart Nicolas
dc.contributor.authorGlover, Isabel
dc.contributor.authorFlecknell, Paul Andrew
dc.date.accessioned2021-08-12T17:55:43Z
dc.date.available2021-08-12T17:55:43Z
dc.date.issued2021-08
dc.date.submitted2019-10-03
dc.identifier.issn0023-6772
dc.identifier.other10.1177_0023677221990706
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/326685
dc.description.abstractThis communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was stimulated, and SEPs were recorded from the motor cortex. The successive administration of three doses of alphaxalone (0.5, 1 and 2 mg/kg) induced an increase of the latency time and a decrease of the amplitude of the SEPs. However, the structure of the waveforms was conserved, and hence alphaxalone might represent a suitable general anaesthetic option in neuroscience research as well as veterinary or human medicine.
dc.languageen
dc.publisherSAGE Publications
dc.subjectShort Report
dc.subjectAlphaxalone
dc.subjectsomatosensory evoked potential
dc.subjectneurosurgery
dc.subjectprimate
dc.titleInfluence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta).
dc.typeArticle
dc.date.updated2021-08-12T17:55:41Z
prism.endingPage366
prism.issueIdentifier4
prism.publicationNameLab Anim
prism.startingPage363
prism.volume55
dc.embargo.termsEmbargo: ends 2021-02-09
dc.identifier.doi10.17863/CAM.74132
dcterms.dateAccepted2020-12-21
rioxxterms.versionofrecord10.1177/0023677221990706
rioxxterms.versionVoR
dc.contributor.orcidBertrand, Henri Georges Michel Justin [0000-0002-1082-8384]
dc.identifier.eissn1758-1117
cam.issuedOnline2021-02-09
rioxxterms.freetoread.startdate2021-02-09


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