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dc.contributor.authorChappell, Joseph Gen
dc.contributor.authorTsoleridis, Theocharisen
dc.contributor.authorClark, Gemmaen
dc.contributor.authorBerry, Louiseen
dc.contributor.authorHolmes, Nadineen
dc.contributor.authorMoore, Christopheren
dc.contributor.authorCarlile, Matthewen
dc.contributor.authorSang, Feien
dc.contributor.authorDebebe, Bisrat Jen
dc.contributor.authorWright, Victoriaen
dc.contributor.authorIrving, William Len
dc.contributor.authorThomson, Brian Jen
dc.contributor.authorBoswell, Timothy CJen
dc.contributor.authorWillingham, Ionaen
dc.contributor.authorJoseph, Ameliaen
dc.contributor.authorSmith, Wendyen
dc.contributor.authorKhakh, Manjinderen
dc.contributor.authorFleming, Vicki Men
dc.contributor.authorLister, Michelle Men
dc.contributor.authorHowson-Wells, Hannah Cen
dc.contributor.authorHolmes, Edward Cen
dc.contributor.authorLoose, Matthew Wen
dc.contributor.authorBall, Jonathan Ken
dc.contributor.authorMcClure, C Patricken
dc.contributor.authorOn Behalf Of The Cog-Uk Consortium,en
dc.date.accessioned2021-08-13T23:30:28Z
dc.date.available2021-08-13T23:30:28Z
dc.date.issued2021-06en
dc.identifier.issn0022-1317
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/326754
dc.description.abstractIn the early phases of the SARS coronavirus type 2 (SARS-CoV-2) pandemic, testing focused on individuals fitting a strict case definition involving a limited set of symptoms together with an identified epidemiological risk, such as contact with an infected individual or travel to a high-risk area. To assess whether this impaired our ability to detect and control early introductions of the virus into the UK, we PCR-tested archival specimens collected on admission to a large UK teaching hospital who retrospectively were identified as having a clinical presentation compatible with COVID-19. In addition, we screened available archival specimens submitted for respiratory virus diagnosis, and dating back to early January 2020, for the presence of SARS-CoV-2 RNA. Our data provides evidence for widespread community circulation of SARS-CoV-2 in early February 2020 and into March that was undetected at the time due to restrictive case definitions informing testing policy. Genome sequence data showed that many of these early cases were infected with a distinct lineage of the virus. Sequences obtained from the first officially recorded case in Nottinghamshire - a traveller returning from Daegu, South Korea - also clustered with these early UK sequences suggesting acquisition of the virus occurred in the UK and not Daegu. Analysis of a larger sample of sequences obtained in the Nottinghamshire area revealed multiple viral introductions, mainly in late February and through March. These data highlight the importance of timely and extensive community testing to prevent future widespread transmission of the virus.
dc.description.sponsorshipWhole genome sequencing of SARS-CoV-2 was funded by COG-UK; COG-UK is supported by funding from the Medical Research Council (MRC) part of UK Research and Innovation (UKRI), the National Institute of Health Research (NIHR) and Genome Research Limited, operating as the Wellcome Sanger Institute.
dc.format.mediumPrinten
dc.languageengen
dc.publisherMicrobiology Society
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectRespiratory Systemen
dc.subjectHumansen
dc.subjectRNA, Viralen
dc.subjectMass Screeningen
dc.subjectRetrospective Studiesen
dc.subjectPhylogenyen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectUnited Kingdomen
dc.subjectCOVID-19en
dc.subjectSARS-CoV-2en
dc.subjectCOVID-19 Nucleic Acid Testingen
dc.titleRetrospective screening of routine respiratory samples revealed undetected community transmission and missed intervention opportunities for SARS-CoV-2 in the United Kingdom.en
dc.typeArticle
prism.issueIdentifier6en
prism.publicationDate2021en
prism.publicationNameThe Journal of general virologyen
prism.volume102en
dc.identifier.doi10.17863/CAM.74202
rioxxterms.versionofrecord10.1099/jgv.0.001595en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-06en
dc.contributor.orcidTsoleridis, Theocharis [0000-0002-9685-6318]
dc.contributor.orcidDebebe, Bisrat J [0000-0002-6551-5641]
dc.identifier.eissn1465-2099
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_PC_19027)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International