Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment.
Cromarty, Ruth A
Donaghy, Paul C
O'Brien, John T
Thomas, Alan J
Cambridge University Press (CUP)
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Hamilton, C. A., Schumacher, J., Matthews, F., Taylor, J., Allan, L., Barnett, N., Cromarty, R. A., et al. (2021). Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment.. Int Psychogeriatr, 1-5. https://doi.org/10.1017/S1041610221001083
Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer's disease (MCI-AD) and may anticipate the onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these etiologies. MCI patients (n = 92) and healthy comparators (n = 31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Associations between qEEG slowing, measured by increased theta/alpha ratio, and clinical progression from MCI to dementia were estimated with a multistate transition model to account for death as a competing risk, while controlling for age, cognitive function, and etiology classified by an expert consensus panel.Over a mean follow-up of 1.5 years (SD = 0.5), 14 cases of incident dementia and 5 deaths were observed. Increased theta/alpha ratio on qEEG was associated with increased annual hazard of dementia (hazard ratio = 1.84, 95% CI: 1.01-3.35). This extends previous findings that MCI-LB features early functional changes, showing that qEEG slowing may anticipate the onset of dementia in prospectively identified MCI.
External DOI: https://doi.org/10.1017/S1041610221001083
This record's URL: https://www.repository.cam.ac.uk/handle/1810/326923
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