Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment.
Cromarty, Ruth A
Donaghy, Paul C
Thomas, Alan J
Cambridge University Press
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Hamilton, C. A., Schumacher, J., Matthews, F., Taylor, J., Allan, L., Barnett, N., Cromarty, R. A., et al. (2021). Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment.. International psychogeriatrics, 1-5. https://doi.org/10.1017/s1041610221001083
Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer’s disease (MCI-AD) and may anticipate onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these aetiologies. MCI patients (n=92) and healthy comparators (n=31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Associations between qEEG slowing, measured by increased theta/alpha ratio, and clinical progression from MCI to dementia were estimated with a multi-state transition model to account for death as a competing risk, while controlling for age, cognitive function, and aetiology classified by an expert consensus panel. Over a mean follow up of 1.5 years (SD = 0.5) fourteen cases of incident dementia and five deaths were observed. Increased theta/alpha ratio on qEEG was associated with increased annual hazard of dementia (Hazard Ratio = 1.84, 95% CI: 1.01–3.35). This extends previous findings that MCI-LB features early functional changes, showing that qEEG slowing may anticipate onset of dementia in prospectively-identified MCI.
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External DOI: https://doi.org/10.1017/s1041610221001083
This record's URL: https://www.repository.cam.ac.uk/handle/1810/326923
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