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dc.contributor.authorHamilton, Calum Aen
dc.contributor.authorSchumacher, Juliaen
dc.contributor.authorMatthews, Fionaen
dc.contributor.authorTaylor, John-Paulen
dc.contributor.authorAllan, Louiseen
dc.contributor.authorBarnett, Nicolaen
dc.contributor.authorCromarty, Ruth Aen
dc.contributor.authorDonaghy, Paul Cen
dc.contributor.authorDurcan, Roryen
dc.contributor.authorFirbank, Michaelen
dc.contributor.authorLawley, Sarahen
dc.contributor.authorO'Brien, Johnen
dc.contributor.authorRoberts, Gemmaen
dc.contributor.authorThomas, Alan Jen
dc.date.accessioned2021-08-18T23:30:29Z
dc.date.available2021-08-18T23:30:29Z
dc.date.issued2021-09-23en
dc.identifier.issn1041-6102
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/326923
dc.description.abstractElectroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer’s disease (MCI-AD) and may anticipate onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these aetiologies. MCI patients (n=92) and healthy comparators (n=31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Associations between qEEG slowing, measured by increased theta/alpha ratio, and clinical progression from MCI to dementia were estimated with a multi-state transition model to account for death as a competing risk, while controlling for age, cognitive function, and aetiology classified by an expert consensus panel. Over a mean follow up of 1.5 years (SD = 0.5) fourteen cases of incident dementia and five deaths were observed. Increased theta/alpha ratio on qEEG was associated with increased annual hazard of dementia (Hazard Ratio = 1.84, 95% CI: 1.01–3.35). This extends previous findings that MCI-LB features early functional changes, showing that qEEG slowing may anticipate onset of dementia in prospectively-identified MCI.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherCambridge University Press
dc.rightsAll rights reserved
dc.titleSlowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment.en
dc.typeArticle
prism.endingPage5
prism.publicationDate2021en
prism.publicationNameInternational psychogeriatricsen
prism.startingPage1
dc.identifier.doi10.17863/CAM.74372
dcterms.dateAccepted2021-07-29en
rioxxterms.versionofrecord10.1017/s1041610221001083en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-09-23en
dc.contributor.orcidHamilton, Calum A [0000-0002-9812-3150]
dc.contributor.orcidSchumacher, Julia [0000-0001-7323-4789]
dc.contributor.orcidDonaghy, Paul C [0000-0001-7195-4846]
dc.contributor.orcidDurcan, Rory [0000-0002-8897-8737]
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
dc.identifier.eissn1741-203X
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successMon Sep 27 07:30:36 BST 2021 - Embargo updated*
cam.orpheus.counter5*
rioxxterms.freetoread.startdate2022-03-23


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