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dc.contributor.authorHamilton, Calum A
dc.contributor.authorSchumacher, Julia
dc.contributor.authorMatthews, Fiona
dc.contributor.authorTaylor, John-Paul
dc.contributor.authorAllan, Louise
dc.contributor.authorBarnett, Nicola
dc.contributor.authorCromarty, Ruth A
dc.contributor.authorDonaghy, Paul C
dc.contributor.authorDurcan, Rory
dc.contributor.authorFirbank, Michael
dc.contributor.authorLawley, Sarah
dc.contributor.authorO'Brien, John T
dc.contributor.authorRoberts, Gemma
dc.contributor.authorThomas, Alan J
dc.date.accessioned2021-08-18T23:30:29Z
dc.date.available2021-08-18T23:30:29Z
dc.date.issued2021-12
dc.identifier.issn1041-6102
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/326923
dc.description.abstractElectroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer's disease (MCI-AD) and may anticipate the onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these etiologies. MCI patients (n = 92) and healthy comparators (n = 31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Associations between qEEG slowing, measured by increased theta/alpha ratio, and clinical progression from MCI to dementia were estimated with a multistate transition model to account for death as a competing risk, while controlling for age, cognitive function, and etiology classified by an expert consensus panel.Over a mean follow-up of 1.5 years (SD = 0.5), 14 cases of incident dementia and 5 deaths were observed. Increased theta/alpha ratio on qEEG was associated with increased annual hazard of dementia (hazard ratio = 1.84, 95% CI: 1.01-3.35). This extends previous findings that MCI-LB features early functional changes, showing that qEEG slowing may anticipate the onset of dementia in prospectively identified MCI.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherCambridge University Press (CUP)
dc.rightsAll rights reserved
dc.titleSlowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment.
dc.typeArticle
prism.endingPage5
prism.publicationDate2021
prism.publicationNameInt Psychogeriatr
prism.startingPage1
dc.identifier.doi10.17863/CAM.74372
dcterms.dateAccepted2021-07-29
rioxxterms.versionofrecord10.1017/S1041610221001083
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-09-23
dc.contributor.orcidHamilton, Calum A [0000-0002-9812-3150]
dc.contributor.orcidSchumacher, Julia [0000-0001-7323-4789]
dc.contributor.orcidDurcan, Rory [0000-0002-8897-8737]
dc.identifier.eissn1741-203X
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-09-23
cam.orpheus.successMon Sep 27 07:30:36 BST 2021 - Embargo updated
cam.orpheus.counter5
rioxxterms.freetoread.startdate2022-03-23


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