Show simple item record

dc.contributor.authorKořený, Luděk
dc.contributor.authorOborník, Miroslav
dc.contributor.authorHoráková, Eva
dc.contributor.authorWaller, Ross F.
dc.contributor.authorLukeš, Julius
dc.date.accessioned2021-09-02T12:31:28Z
dc.date.available2021-09-02T12:31:28Z
dc.date.issued2021-09-02
dc.date.submitted2020-12-16
dc.identifier.issn1464-7931
dc.identifier.issn1469-185X
dc.identifier.otherbrv12794
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/327497
dc.description.abstractABSTRACT: The capacity of haem to transfer electrons, bind diatomic gases, and catalyse various biochemical reactions makes it one of the essential biomolecules on Earth and one that was likely used by the earliest forms of cellular life. Since the description of haem biosynthesis, our understanding of this multi‐step pathway has been almost exclusively derived from a handful of model organisms from narrow taxonomic contexts. Recent advances in genome sequencing and functional studies of diverse and previously neglected groups have led to discoveries of alternative routes of haem biosynthesis that deviate from the ‘classical’ pathway. In this review, we take an evolutionarily broad approach to illuminate the remarkable diversity and adaptability of haem synthesis, from prokaryotes to eukaryotes, showing the range of strategies that organisms employ to obtain and utilise haem. In particular, the complex evolutionary histories of eukaryotes that involve multiple endosymbioses and horizontal gene transfers are reflected in the mosaic origin of numerous metabolic pathways with haem biosynthesis being a striking case. We show how different evolutionary trajectories and distinct life strategies resulted in pronounced tensions and differences in the spatial organisation of the haem biosynthesis pathway, in some cases leading to a complete loss of a haem‐synthesis capacity and, rarely, even loss of a requirement for haem altogether.
dc.languageen
dc.publisherBlackwell Publishing Ltd
dc.subjectOriginal Article
dc.subjectOriginal Articles
dc.subjecttetrapyrrole
dc.subjectporphyrin
dc.subjectmetabolic pathways
dc.subjectevolution
dc.subjecteukaryogenesis
dc.subjectmitochondrion
dc.subjectchloroplast
dc.subjectphotosynthesis
dc.subjectiron metabolism
dc.titleThe convoluted history of haem biosynthesis
dc.typeArticle
dc.date.updated2021-09-02T12:31:27Z
prism.publicationNameBiological Reviews
dc.identifier.doi10.17863/CAM.74950
dcterms.dateAccepted2021-08-19
rioxxterms.versionofrecord10.1111/brv.12794
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.contributor.orcidOborník, Miroslav [0000-0003-4819-7319]
pubs.funder-project-idCzech Science Foundation grant (20‐07186S, 21‐03224S, 21‐09283S)
pubs.funder-project-idERC CZ (LL1601)
pubs.funder-project-idERD funds of the Czech Ministry of Education (CZ.02.1.01/0.0/0.0/16_019/0000759)
pubs.funder-project-idWellcome Investigator Award (214298/Z/18/Z)


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record