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Computational de-orphaning of Mycobacterium tuberculosis targets

Published version
Peer-reviewed

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Type

Book chapter

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Authors

Bishi, Lorraine Yamurai 
Vedithi, SC 
Blundell, Tom L 
Mugumbate, Grace Chitima 

Abstract

Tuberculosis (TB) continues to be a major health hazard worldwide due to the resurgence of drug discovery strains of Mycobacterium tuberculosis (Mtb) and co-infection. For decades drug discovery has concentrated on identifying ligands for ~10 Mtb targets, hence most of the identified essential proteins are not utilised in TB chemotherapy. Here computational techniques were used to identify ligands for the orphan Mtb proteins. These range from ligand-based and structure-based virtual screening modelling the proteome of the bacterium. Identification of ligands for most of the Mtb Proteins will provide novel TB drugs and targets and hence address drug resistance, toxicity and the duration of TB treatment.

Description

Title

Computational de-orphaning of Mycobacterium tuberculosis targets

Keywords

3 Good Health and Well Being

Is Part Of

Tuberculosis - Beyond the Biomedical

Book type

Publisher

IntechOpen

ISBN

Sponsorship
Bill & Melinda Gates Foundation (via Foundation for the National Institutes of Health (FNIH)) (BLUN17STB)
American Leprosy Missions (unknown)