Computational de-orphaning of Mycobacterium tuberculosis targets
Published version
Peer-reviewed
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Repository DOI
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Authors
Bishi, Lorraine Yamurai
Vedithi, SC
Blundell, Tom L
Mugumbate, Grace Chitima
Abstract
Tuberculosis (TB) continues to be a major health hazard worldwide due to the resurgence of drug discovery strains of Mycobacterium tuberculosis (Mtb) and co-infection. For decades drug discovery has concentrated on identifying ligands for ~10 Mtb targets, hence most of the identified essential proteins are not utilised in TB chemotherapy. Here computational techniques were used to identify ligands for the orphan Mtb proteins. These range from ligand-based and structure-based virtual screening modelling the proteome of the bacterium. Identification of ligands for most of the Mtb Proteins will provide novel TB drugs and targets and hence address drug resistance, toxicity and the duration of TB treatment.
Description
Title
Computational de-orphaning of Mycobacterium tuberculosis targets
Keywords
3 Good Health and Well Being
Is Part Of
Tuberculosis - Beyond the Biomedical
Book type
Publisher
IntechOpen
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ISBN
Sponsorship
Bill & Melinda Gates Foundation (via Foundation for the National Institutes of Health (FNIH)) (BLUN17STB)
American Leprosy Missions (unknown)
American Leprosy Missions (unknown)