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dc.contributor.authorBocchetta, Martina
dc.contributor.authorMalpetti, Maura
dc.contributor.authorTodd, Emily G
dc.contributor.authorRowe, James
dc.contributor.authorRohrer, Jonathan D
dc.date.accessioned2021-09-16T23:30:53Z
dc.date.available2021-09-16T23:30:53Z
dc.date.issued2021
dc.identifier.issn2632-1297
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/328151
dc.description.abstractWhilst initial anatomical studies of frontotemporal dementia focussed on cortical involvement, the relevance of subcortical structures to the pathophysiology of frontotemporal dementia has been increasingly recognized over recent years. Key structures affected include the caudate, putamen, nucleus accumbens, and globus pallidus within the basal ganglia, the hippocampus and amygdala within the medial temporal lobe, the basal forebrain, and the diencephalon structures of the thalamus, hypothalamus and habenula. At the most posterior aspect of the brain, focal involvement of brainstem and cerebellum has recently also been shown in certain subtypes of frontotemporal dementia. Many of the neuroimaging studies on subcortical structures in frontotemporal dementia have been performed in clinically defined sporadic cases. However, investigations of genetically- and pathologically-confirmed forms of frontotemporal dementia are increasingly common and provide molecular specificity to the changes observed. Furthermore, detailed analyses of sub-nuclei and subregions within each subcortical structure are being added to the literature, allowing refinement of the patterns of subcortical involvement. This review focuses on the existing literature on structural imaging and neuropathological studies of subcortical anatomy across the spectrum of frontotemporal dementia, along with investigations of brain-behaviour correlates that examine the cognitive sequelae of specific subcortical involvement: it aims to 'look beneath the surface' and summarize the patterns of subcortical involvement have been described in frontotemporal dementia.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleLooking beneath the surface: the importance of subcortical structures in frontotemporal dementia.
dc.typeArticle
prism.issueIdentifier3
prism.publicationDate2021
prism.publicationNameBrain Commun
prism.startingPagefcab158
prism.volume3
dc.identifier.doi10.17863/CAM.75606
dcterms.dateAccepted2021-05-21
rioxxterms.versionofrecord10.1093/braincomms/fcab158
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-01
dc.contributor.orcidBocchetta, Martina [0000-0003-1814-5024]
dc.contributor.orcidMalpetti, Maura [0000-0001-8923-9656]
dc.contributor.orcidTodd, Emily G [0000-0003-1551-5691]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn2632-1297
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
cam.issuedOnline2021-07-16


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International