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A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Published version
Peer-reviewed

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Authors

Garcia-Carreras, Bernardo 
Hitchings, Matt D. T. 
Katzelnick, Leah C.  ORCID logo  https://orcid.org/0000-0003-1033-6758

Abstract

Abstract: Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.

Description

Funder: John A Watson Faculty Scholar fellowship

Keywords

Article, /631/250/2152/2153/1291, /631/326/596/4130, /631/326/596/2553, /692/699/255/2514, article

Journal Title

Nature Communications

Conference Name

Journal ISSN

2041-1723

Volume Title

11

Publisher

Nature Publishing Group UK
Sponsorship
U.S. Department of Health & Human Services | National Institutes of Health (NIH) (DP2LM013102)
Burroughs Wellcome Fund (BWF) (Career Award at the Scientific Interface)