Signalling to intracellular Ca2+ channels
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Abstract
Ryanodine receptors (RyR), expressed within the ER or plasma membrane (PM), may contribute to regulated insulin secretion from pancreatic β-cells. Amplification by RyR of the Ca
Previous work established that in HEK cells expressing type 1 parathyroid hormone receptors (PTH
Inhibition of AC with SQ22536 and 2′,5′-dideoxyadenosine reduced the amounts of cAMP produced by acute and sustained stimulation with PTH(1-34) by ~80%, but they had no effect on potentiation of carbachol-evoked Ca