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dc.contributor.authorEngstrand, J
dc.contributor.authorAbreu de Carvalho, LF
dc.contributor.authorAghayan, D
dc.contributor.authorBalakrishnan, A
dc.contributor.authorBelli, A
dc.contributor.authorBjörnsson, B
dc.contributor.authorDasari, BVM
dc.contributor.authorDetry, O
dc.contributor.authorDi Martino, M
dc.contributor.authorEdwin, B
dc.contributor.authorErdmann, J
dc.contributor.authorFristedt, R
dc.contributor.authorFusai, G
dc.contributor.authorGimenez-Maurel, T
dc.contributor.authorHemmingsson, O
dc.contributor.authorHidalgo Salinas, C
dc.contributor.authorIsaksson, B
dc.contributor.authorIvanecz, A
dc.contributor.authorIzzo, F
dc.contributor.authorKnoefel, WT
dc.contributor.authorKron, P
dc.contributor.authorLehwald-Tywuschik, N
dc.contributor.authorLesurtel, M
dc.contributor.authorLodge, JPA
dc.contributor.authorMachairas, N
dc.contributor.authorMarino, MV
dc.contributor.authorMartin, V
dc.contributor.authorPaterson, A
dc.contributor.authorRystedt, J
dc.contributor.authorSandström, P
dc.contributor.authorSerrablo, A
dc.contributor.authorSiriwardena, AK
dc.contributor.authorTaflin, H
dc.contributor.authorvan Gulik, TM
dc.contributor.authorYaqub, S
dc.contributor.authorÖzden, I
dc.contributor.authorRamia, JM
dc.contributor.authorSturesson, C
dc.contributor.authorE-AHPBA Scientific and Research Committee
dc.date.accessioned2021-09-25T00:35:24Z
dc.date.available2021-09-25T00:35:24Z
dc.date.issued2021-07-06
dc.identifier.issn2474-9842
dc.identifier.other34426830
dc.identifier.otherPMC8382975
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/328517
dc.descriptionFunder: Region Stockholm
dc.descriptionFunder: Region Stockholm (clinical postdoctoral appointment)
dc.description.abstractBACKGROUND: Limited evidence exists to guide the management of patients with liver metastases from squamous cell carcinoma (SCC). The aim of this retrospective multicentre cohort study was to describe patterns of disease recurrence after liver resection/ablation for SCC liver metastases and factors associated with recurrence-free survival (RFS) and overall survival (OS). METHOD: Members of the European-African Hepato-Pancreato-Biliary Association were invited to include all consecutive patients undergoing liver resection/ablation for SCC liver metastases between 2002 and 2019. Patient, tumour and perioperative characteristics were analysed with regard to RFS and OS. RESULTS: Among the 102 patients included from 24 European centres, 56 patients had anal cancer, and 46 patients had SCC from other origin. RFS in patients with anal cancer and non-anal cancer was 16 and 9 months, respectively (P = 0.134). A positive resection margin significantly influenced RFS for both anal cancer and non-anal cancer liver metastases (hazard ratio 6.82, 95 per cent c.i. 2.40 to 19.35, for the entire cohort). Median survival duration and 5-year OS rate among patients with anal cancer and non-anal cancer were 50 months and 45 per cent and 21 months and 25 per cent, respectively. For the entire cohort, only non-radical resection was associated with worse overall survival (hazard ratio 3.21, 95 per cent c.i. 1.24 to 8.30). CONCLUSION: Liver resection/ablation of liver metastases from SCC can result in long-term survival. Survival was superior in treated patients with liver metastases from anal versus non-anal cancer. A negative resection margin is paramount for acceptable outcome.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2474-9842
dc.sourcenlmid: 101722685
dc.titleLiver resection and ablation for squamous cell carcinoma liver metastases.
dc.typeArticle
dc.date.updated2021-09-25T00:35:23Z
prism.issueIdentifier4
prism.publicationNameBJS Open
prism.volume5
dc.identifier.doi10.17863/CAM.75965
dcterms.dateAccepted2021-05-17
rioxxterms.versionofrecord10.1093/bjsopen/zrab060
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidEngstrand, J [0000-0003-1123-7022]
dc.contributor.orcidAghayan, D [0000-0001-7051-3512]
dc.contributor.orcidBelli, A [0000-0002-6252-573X]
dc.contributor.orcidDetry, O [0000-0002-9436-6673]
dc.contributor.orcidDi Martino, M [0000-0001-6510-7210]
dc.contributor.orcidHemmingsson, O [0000-0003-1732-168X]
dc.contributor.orcidLesurtel, M [0000-0003-2397-4599]
dc.contributor.orcidLodge, JPA [0000-0001-8771-4214]
dc.contributor.orcidMachairas, N [0000-0003-3239-3905]
dc.contributor.orcidMarino, MV [0000-0002-0466-4467]
dc.contributor.orcidRystedt, J [0000-0002-8865-9963]
dc.contributor.orcidYaqub, S [0000-0002-5696-2319]
dc.contributor.orcidRamia, JM [0000-0001-7734-9479]
dc.contributor.orcidSturesson, C [0000-0003-3451-2840]
dc.identifier.eissn2474-9842
cam.issuedOnline2021-08-24


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International