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dc.contributor.authorShrestha, Nirajan
dc.contributor.authorMelvin, Steven D
dc.contributor.authorMcKeating, Daniel R
dc.contributor.authorHolland, Olivia J
dc.contributor.authorCuffe, James SM
dc.contributor.authorPerkins, Anthony V
dc.contributor.authorMcAinch, Andrew J
dc.contributor.authorHryciw, Deanne H
dc.date.accessioned2021-09-25T23:21:58Z
dc.date.available2021-09-25T23:21:58Z
dc.date.issued2021-09-23
dc.identifier.issn1422-0067
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/328533
dc.description.abstractBACKGROUND: Linoleic acid (LA) is an essential polyunsaturated fatty acid (PUFA) that is required for foetal growth and development. Excess intake of LA can be detrimental for metabolic health due to its pro-inflammatory properties; however, the effect of a diet high in LA on offspring metabolites is unknown. In this study, we aimed to determine the role of maternal or postnatal high linoleic acid (HLA) diet on plasma metabolites in adult offspring. METHODS: Female Wistar Kyoto (WKY) rats were fed with either low LA (LLA) or HLA diet for 10 weeks prior to conception and during gestation/lactation. Offspring were weaned at postnatal day 25 (PN25), treated with either LLA or HLA diets and sacrificed at PN180. Metabolite analysis was performed in plasma samples using Nuclear Magnetic Resonance. RESULTS: Maternal and postnatal HLA diet did not alter plasma metabolites in male and female adult offspring. There was no specific clustering among different treatment groups as demonstrated by principal component analysis. Interestingly, there was clustering among male and female offspring independent of maternal and postnatal dietary intervention. Lysine was higher in female offspring, while 3-hydroxybutyric acid and acetic acid were significantly higher in male offspring. CONCLUSION: In summary, maternal or postnatal HLA diet did not alter the plasma metabolites in the adult rat offspring; however, differences in metabolites between male and female offspring occurred independently of dietary intervention.
dc.languageen
dc.publisherMDPI AG
dc.subjectlinoleic acid
dc.subjectsex
dc.subjectmetabolite
dc.subjectoffspring
dc.titleSex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet.
dc.typeArticle
dc.date.updated2021-09-25T23:21:56Z
prism.issueIdentifier19
prism.publicationNameInt J Mol Sci
prism.volume22
dc.identifier.doi10.17863/CAM.75981
dcterms.dateAccepted2021-09-21
rioxxterms.versionofrecord10.3390/ijms221910223
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidShrestha, Nirajan [0000-0003-1259-0661]
dc.contributor.orcidHolland, Olivia J [0000-0002-5798-5264]
dc.contributor.orcidCuffe, James SM [0000-0002-2675-8149]
dc.contributor.orcidPerkins, Anthony V [0000-0002-9829-6772]
dc.contributor.orcidMcAinch, Andrew J [0000-0002-8762-4865]
dc.contributor.orcidHryciw, Deanne H [0000-0003-1697-8890]
dc.identifier.eissn1422-0067
pubs.funder-project-idAllen Foundation (N/A)
cam.issuedOnline2021-09-23


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