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dc.contributor.authorElmentaite, Rasa
dc.contributor.authorKumasaka, Natsuhiko
dc.contributor.authorRoberts, Kenny
dc.contributor.authorFleming, Aaron
dc.contributor.authorDann, Emma
dc.contributor.authorKing, Hamish W.
dc.contributor.authorKleshchevnikov, Vitalii
dc.contributor.authorDabrowska, Monika
dc.contributor.authorPritchard, Sophie
dc.contributor.authorBolt, Liam
dc.contributor.authorVieira, Sara F.
dc.contributor.authorMamanova, Lira
dc.contributor.authorHuang, Ni
dc.contributor.authorPerrone, Francesca
dc.contributor.authorGoh Kai’En, Issac
dc.contributor.authorLisgo, Steven N.
dc.contributor.authorKatan, Matilda
dc.contributor.authorLeonard, Steven
dc.contributor.authorOliver, Thomas R. W.
dc.contributor.authorHook, C. Elizabeth
dc.contributor.authorNayak, Komal
dc.contributor.authorCampos, Lia S.
dc.contributor.authorDomínguez Conde, Cecilia
dc.contributor.authorStephenson, Emily
dc.contributor.authorEngelbert, Justin
dc.contributor.authorBotting, Rachel A.
dc.contributor.authorPolanski, Krzysztof
dc.contributor.authorvan Dongen, Stijn
dc.contributor.authorPatel, Minal
dc.contributor.authorMorgan, Michael D.
dc.contributor.authorMarioni, John C.
dc.contributor.authorBayraktar, Omer Ali
dc.contributor.authorMeyer, Kerstin B.
dc.contributor.authorHe, Xiaoling
dc.contributor.authorBarker, Roger A.
dc.contributor.authorUhlig, Holm H.
dc.contributor.authorMahbubani, Krishnaa T.
dc.contributor.authorSaeb-Parsy, Kourosh
dc.contributor.authorZilbauer, Matthias
dc.contributor.authorClatworthy, Menna R.
dc.contributor.authorHaniffa, Muzlifah
dc.contributor.authorJames, Kylie R.
dc.contributor.authorTeichmann, Sarah A.
dc.date.accessioned2021-09-28T15:29:36Z
dc.date.available2021-09-28T15:29:36Z
dc.date.issued2021-09-08
dc.date.submitted2020-11-24
dc.identifier.issn0028-0836
dc.identifier.others41586-021-03852-1
dc.identifier.other3852
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/328647
dc.description.abstractAbstract: The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell lineages, we use single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions in the developing and up to 11 distinct anatomical regions in the healthy paediatric and adult human gut. This reveals the existence of transcriptionally distinct BEST4 epithelial cells throughout the human intestinal tract. Furthermore, we implicate IgG sensing as a function of intestinal tuft cells. We describe neural cell populations in the developing enteric nervous system, and predict cell-type-specific expression of genes associated with Hirschsprung’s disease. Finally, using a systems approach, we identify key cell players that drive the formation of secondary lymphoid tissue in early human development. We show that these programs are adopted in inflammatory bowel disease to recruit and retain immune cells at the site of inflammation. This catalogue of intestinal cells will provide new insights into cellular programs in development, homeostasis and disease.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/631/114/2391
dc.subject/631/136
dc.subject/692/699/1503/257/1402
dc.subject/38/91
dc.subject/45
dc.subject/38/39
dc.subject/14
dc.subject/14/32
dc.subjectarticle
dc.titleCells of the human intestinal tract mapped across space and time
dc.typeArticle
dc.date.updated2021-09-28T15:29:34Z
prism.endingPage255
prism.issueIdentifier7875
prism.publicationNameNature
prism.startingPage250
prism.volume597
dc.identifier.doi10.17863/CAM.76097
dcterms.dateAccepted2021-07-26
rioxxterms.versionofrecord10.1038/s41586-021-03852-1
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidElmentaite, Rasa [0000-0001-7366-5466]
dc.contributor.orcidKumasaka, Natsuhiko [0000-0002-3557-0375]
dc.contributor.orcidRoberts, Kenny [0000-0001-6155-0821]
dc.contributor.orcidDann, Emma [0000-0002-7400-7438]
dc.contributor.orcidKing, Hamish W. [0000-0001-5972-8926]
dc.contributor.orcidBolt, Liam [0000-0001-7293-0774]
dc.contributor.orcidVieira, Sara F. [0000-0002-1021-3021]
dc.contributor.orcidMamanova, Lira [0000-0003-1463-8622]
dc.contributor.orcidKatan, Matilda [0000-0001-9992-8375]
dc.contributor.orcidOliver, Thomas R. W. [0000-0003-4306-0102]
dc.contributor.orcidDomínguez Conde, Cecilia [0000-0002-8684-4655]
dc.contributor.orcidBotting, Rachel A. [0000-0001-9595-4605]
dc.contributor.orcidPolanski, Krzysztof [0000-0002-2586-9576]
dc.contributor.orcidMorgan, Michael D. [0000-0003-0757-0711]
dc.contributor.orcidMarioni, John C. [0000-0001-9092-0852]
dc.contributor.orcidBayraktar, Omer Ali [0000-0001-6055-277X]
dc.contributor.orcidMeyer, Kerstin B. [0000-0001-5906-1498]
dc.contributor.orcidUhlig, Holm H. [0000-0002-6111-7355]
dc.contributor.orcidMahbubani, Krishnaa T. [0000-0002-1327-2334]
dc.contributor.orcidSaeb-Parsy, Kourosh [0000-0002-0633-3696]
dc.contributor.orcidZilbauer, Matthias [0000-0002-7272-0547]
dc.contributor.orcidHaniffa, Muzlifah [0000-0002-3927-2084]
dc.contributor.orcidJames, Kylie R. [0000-0002-7107-0650]
dc.contributor.orcidTeichmann, Sarah A. [0000-0002-6294-6366]
dc.identifier.eissn1476-4687


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