The risk of cardiovascular disease in women after miscarriage, stillbirth, and therapeutic abortion: a protocol for a systematic review and meta-analysis
Authors
Muehlschlegel, Charlotte
Kyriacou, Harry
Al-Mohammad, Abdulrahman
Foster-Davies, Lowri A.
Simmons-Jones, Fiona
Publication Date
2020-10-07Journal Title
Systematic Reviews
Publisher
BioMed Central
Volume
9
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Muehlschlegel, C., Kyriacou, H., Al-Mohammad, A., Foster-Davies, L. A., Simmons-Jones, F., & Oliver-Williams, C. (2020). The risk of cardiovascular disease in women after miscarriage, stillbirth, and therapeutic abortion: a protocol for a systematic review and meta-analysis. Systematic Reviews, 9 (1) https://doi.org/10.1186/s13643-020-01444-0
Description
Funder: Homerton College, University of Cambridge (GB)
Funder: National Institute for Health Research; doi: http://dx.doi.org/10.13039/501100000272
Abstract
Abstract: Background: Cardiovascular disease (CVD) is the leading cause of death in women, responsible for approximately a third of all female deaths. Pregnancy complications are known to be associated with a greater risk of incident CVD in mothers. However, the relationships between pregnancy loss due to miscarriage, stillbirth, or therapeutic abortion, and future maternal cardiovascular health are under-researched. This study seeks to provide an up-to-date systematic review and meta-analysis of the relationship between these three forms of pregnancy loss and the subsequent development of CVD. Methods: This systematic review will follow the Preferred Reporting Items for Systematic Review and Meta-Analysis checklist (PRISMA) and the Meta-analyses Of Observational Studies in Epidemiology (MOOSE) Checklist. A systematic search will be undertaken using publications identified in MEDLINE (PubMed), Scopus, Web of Knowledge, the CINAHL Nursing Database, and the Cochrane Library. The eligibility of each publication will be determined by predefined selection criteria. The quality of the included studies will be rated using the Newcastle-Ottawa Scale. Pooled measures of association will be computed using random-effects model meta-analyses. Between-study heterogeneity will be assessed using the I2 statistic and the Cochrane χ2 statistic. Small study effects will be evaluated for meta-analyses with sufficient studies through the use of funnel plots and Egger’s test. Discussion: The results of this systematic review will discuss the long-term risks of multiple types of cardiovascular disease in women who have experienced miscarriage, stillbirth, and/or therapeutic abortion. It will contribute to the growing field of cardio-obstetrics as the first to consider the full breadth of literature regarding the association between all forms of pregnancy loss and future maternal cardiovascular disease. Systematic review registration: PROSPERO registration number [CRD42020167587]
Keywords
Protocol, Miscarriage, Stillbirth, Abortion, Cardiovascular disease, Coronary heart disease, Stroke, Systematic review, Meta-analysis
Sponsorship
Medical Research Council (MR/L003120/1)
British Heart Foundation (GB) (RG/13/13/30194)
Identifiers
s13643-020-01444-0, 1444
External DOI: https://doi.org/10.1186/s13643-020-01444-0
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329082
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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