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Tracheal intubation in traumatic brain injury: a multicentre prospective observational study.

Published version
Peer-reviewed

Type

Article

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Authors

Gravesteijn, Benjamin Yael 
Sewalt, Charlie Aletta 
Nieboer, Daan 
Menon, David Krishna 
Maas, Andrew 

Abstract

BACKGROUND: We aimed to study the associations between pre- and in-hospital tracheal intubation and outcomes in traumatic brain injury (TBI), and whether the association varied according to injury severity. METHODS: Data from the international prospective pan-European cohort study, Collaborative European NeuroTrauma Effectiveness Research for TBI (CENTER-TBI), were used (n=4509). For prehospital intubation, we excluded self-presenters. For in-hospital intubation, patients whose tracheas were intubated on-scene were excluded. The association between intubation and outcome was analysed with ordinal regression with adjustment for the International Mission for Prognosis and Analysis of Clinical Trials in TBI variables and extracranial injury. We assessed whether the effect of intubation varied by injury severity by testing the added value of an interaction term with likelihood ratio tests. RESULTS: In the prehospital analysis, 890/3736 (24%) patients had their tracheas intubated at scene. In the in-hospital analysis, 460/2930 (16%) patients had their tracheas intubated in the emergency department. There was no adjusted overall effect on functional outcome of prehospital intubation (odds ratio=1.01; 95% confidence interval, 0.79-1.28; P=0.96), and the adjusted overall effect of in-hospital intubation was not significant (odds ratio=0.86; 95% confidence interval, 0.65-1.13; P=0.28). However, prehospital intubation was associated with better functional outcome in patients with higher thorax and abdominal Abbreviated Injury Scale scores (P=0.009 and P=0.02, respectively), whereas in-hospital intubation was associated with better outcome in patients with lower Glasgow Coma Scale scores (P=0.01): in-hospital intubation was associated with better functional outcome in patients with Glasgow Coma Scale scores of 10 or lower. CONCLUSION: The benefits and harms of tracheal intubation should be carefully evaluated in patients with TBI to optimise benefit. This study suggests that extracranial injury should influence the decision in the prehospital setting, and level of consciousness in the in-hospital setting. CLINICAL TRIAL REGISTRATION: NCT02210221.

Description

Keywords

Europe, effectiveness, neurological outcome, prehospital, tracheal intubation, traumatic brain injury, Adult, Aged, Brain Injuries, Traumatic, Female, Humans, Intubation, Intratracheal, Male, Middle Aged, Prospective Studies, Trauma Severity Indices

Journal Title

Br J Anaesth

Conference Name

Journal ISSN

0007-0912
1471-6771

Volume Title

125

Publisher

Elsevier BV
Sponsorship
European Commission (602150)
Academy of Medical Sciences (unknown)