T lymphocyte senescence is attenuated in Parkinson's disease.
Scott, Kirsten M
Solim, Imtiaz H
Journal of neuroinflammation
MetadataShow full item record
Kouli, A., Jensen, M., Papastavrou, V., Scott, K. M., Kolenda, C., Parker, C., Solim, I. H., et al. (2021). T lymphocyte senescence is attenuated in Parkinson's disease.. Journal of neuroinflammation, 18 (1), 228. https://doi.org/10.1186/s12974-021-02287-9
Immune involvement is well-described in Parkinson’s disease (PD), including an adaptive T lymphocyte response. Given the increasing prevalence of Parkinson’s disease in older age, age-related dysregulation of T lymphocytes may be relevant in this disorder, and we have previously observed changes in age-associated CD8+ T cell subsets in mid-stage PD. This study aimed to further characterise T cell immunosenescence in newly-diagnosed PD patients, including shifts in CD4+ and CD8+ subpopulations, and changes in markers of cellular ageing in CD8+ T lymphocytes.
Michael J. Fox Foundation (MJFF) (14912)
WELLCOME TRUST (106565/Z/14/Z)
Embargo Lift Date
External DOI: https://doi.org/10.1186/s12974-021-02287-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329128
All rights reserved