Synaptic tau: A pathological or physiological phenomenon?
Acta neuropathologica communications
MetadataShow full item record
Robbins, M., Clayton, E., & Kaminski Schierle, G. S. (2021). Synaptic tau: A pathological or physiological phenomenon?. Acta neuropathologica communications, 9 (1) https://doi.org/10.1186/s40478-021-01246-y
Funder: infinitus china ltd.
In this review, we discuss the synaptic aspects of Tau pathology occurring during Alzheimer's disease (AD) and how this may relate to memory impairment, a major hallmark of AD. Whilst the clinical diagnosis of AD patients is a loss of working memory and long-term declarative memory, the histological diagnosis is the presence of neurofibrillary tangles of hyperphosphorylated Tau and Amyloid-beta plaques. Tau pathology spreads through synaptically connected neurons to impair synaptic function preceding the formation of neurofibrillary tangles, synaptic loss, axonal retraction and cell death. Alongside synaptic pathology, recent data suggest that Tau has physiological roles in the pre- or post- synaptic compartments. Thus, we have seen a shift in the research focus from Tau as a microtubule-stabilising protein in axons, to Tau as a synaptic protein with roles in accelerating spine formation, dendritic elongation, and in synaptic plasticity coordinating memory pathways. We collate here the myriad of emerging interactions and physiological roles of synaptic Tau, and discuss the current evidence that synaptic Tau contributes to pathology in AD.
Synapses, Memory, Plasticity, Tau, Neurodegeneration, Alzheimer’s disease
Wellcome Trust (065807/Z/01/Z, 203249/Z/16/Z)
medical research council (MR/K02292X/1)
michael j. fox foundation for parkinson's research (16238)
wellcome trust (065807/Z/01/Z, 203249/Z/16/Z)
alzheimer’s research uk (ARUK-PG013-14)
engineering and physical sciences research council (EP/L015889/1)
Medical Research Council (MR/K02292X/1)
External DOI: https://doi.org/10.1186/s40478-021-01246-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329328
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: firstname.lastname@example.org