T lymphocyte senescence is attenuated in Parkinson’s disease
Scott, Kirsten M.
Solim, Imtiaz H.
Williams-Gray, Caroline H.
Journal of Neuroinflammation
MetadataShow full item record
Kouli, A., Jensen, M., Papastavrou, V., Scott, K. M., Kolenda, C., Parker, C., Solim, I. H., et al. (2021). T lymphocyte senescence is attenuated in Parkinson’s disease. Journal of Neuroinflammation, 18 (1) https://doi.org/10.1186/s12974-021-02287-9
Abstract: Background: Immune involvement is well-described in Parkinson’s disease (PD), including an adaptive T lymphocyte response. Given the increasing prevalence of Parkinson’s disease in older age, age-related dysregulation of T lymphocytes may be relevant in this disorder, and we have previously observed changes in age-associated CD8+ T cell subsets in mid-stage PD. This study aimed to further characterise T cell immunosenescence in newly diagnosed PD patients, including shifts in CD4+ and CD8+ subpopulations, and changes in markers of cellular ageing in CD8+ T lymphocytes. Methods: Peripheral blood mononuclear cells were extracted from the blood of 61 newly diagnosed PD patients and 63 age- and sex-matched controls. Flow cytometric analysis was used for immunophenotyping of CD8+ and CD4+ lymphocyte subsets, and analysis of recent thymic emigrant cells. Telomere length within CD8+ T lymphocytes was assessed, as well as the expression of the telomerase reverse transcriptase enzyme (hTERT), and the cell-ageing markers p16INK4a and p21CIP1/Waf1. Results: The number of CD8+ TEMRA T cells was found to be significantly reduced in PD patients compared to controls. The expression of p16INK4a in CD8+ lymphocytes was also lower in patients versus controls. Chronic latent CMV infection was associated with increased senescent CD8+ lymphocytes in healthy controls, but this shift was less apparent in PD patients. Conclusions: Taken together, our data demonstrate a reduction in CD8+ T cell replicative senescence which is present at the earliest stages of Parkinson’s disease.
Research, Parkinson’s disease, Immunosenescence, T lymphocytes, Ageing markers
michael j. fox foundation for parkinson's research (14912)
medical research council (MR/R007446/1)
External DOI: https://doi.org/10.1186/s12974-021-02287-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329352