Metabolomics in early life and the association with body composition at age 2 years
Snowden, Stuart G.
Myers, Pernille Neve
van de Heijning, Bert
Ong, Ken K.
Dunger, David B.
Hokken‐Koelega, Anita C.S.
John Wiley & Sons, Inc.
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van Beijsterveldt, I. A., Snowden, S. G., Myers, P. N., de Fluiter, K. S., van de Heijning, B., Brix, S., Ong, K. K., et al. (2021). Metabolomics in early life and the association with body composition at age 2 years. Pediatric Obesity https://doi.org/10.1111/ijpo.12859
Funder: Danone Nutricia Research; Id: http://dx.doi.org/10.13039/100015766
Summary: Background and Objectives: Early life is a critical window for adiposity programming. Metabolic‐profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic‐profile at 3 months of age is predictive for body composition at 2 years and if there are differences between boys and girls and between infant feeding types. Methods: In 318 healthy term‐born infants, we determined body composition with skinfold measurements and abdominal ultrasound at 3 months and 2 years of age. High‐throughput‐metabolic‐profiling was performed on 3‐month‐blood‐samples. Using random‐forest‐machine‐learning‐models, we studied if the metabolic‐profile at 3 months can predict body composition outcomes at 2 years of age. Results: Plasma metabolite‐profile at 3 months was found to predict body composition at 2 years, based on truncal: peripheral‐fat‐skinfold‐ratio (T:P‐ratio), with a predictive value of 75.8%, sensitivity of 100% and specificity of 50%. Predictive value was higher in boys (Q2 = 0.322) than girls (Q2 = 0.117). Of the 15 metabolite variables most strongly associated with T:P‐ratio, 11 were also associated with visceral fat at 2 years of age. Conclusion: Several plasma metabolites (LysoPC(22:2), dimethylarginine and others) at 3 months associate with body composition outcome at 2 years. These results highlight the importance of the first months of life for adiposity programming.
ORIGINAL RESEARCH, adiposity, body composition, infants, metabolomics, skinfolds
Biotechnology and Biological Sciences Research Council (BB/P028195/1)
EU Commission ‐ JPI HDHL program (696295)
Medical Research Council (MC_UU_00006/2)
NIHR Cambridge Biomedical Research Centre (146281)
External DOI: https://doi.org/10.1111/ijpo.12859
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329394