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dc.contributor.authorvan Beijsterveldt, Inge A.L.P.
dc.contributor.authorSnowden, Stuart G.
dc.contributor.authorMyers, Pernille Neve
dc.contributor.authorde Fluiter, Kirsten S.
dc.contributor.authorvan de Heijning, Bert
dc.contributor.authorBrix, Susanne
dc.contributor.authorOng, Ken K.
dc.contributor.authorDunger, David B.
dc.contributor.authorHokken‐Koelega, Anita C.S.
dc.contributor.authorKoulman, Albert
dc.date.accessioned2021-10-14T01:29:42Z
dc.date.available2021-10-14T01:29:42Z
dc.date.issued2021-10-13
dc.date.submitted2021-04-07
dc.identifier.issn2047-6302
dc.identifier.issn2047-6310
dc.identifier.otherijpo12859
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329394
dc.descriptionFunder: Danone Nutricia Research; Id: http://dx.doi.org/10.13039/100015766
dc.description.abstractSummary: Background and Objectives: Early life is a critical window for adiposity programming. Metabolic‐profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic‐profile at 3 months of age is predictive for body composition at 2 years and if there are differences between boys and girls and between infant feeding types. Methods: In 318 healthy term‐born infants, we determined body composition with skinfold measurements and abdominal ultrasound at 3 months and 2 years of age. High‐throughput‐metabolic‐profiling was performed on 3‐month‐blood‐samples. Using random‐forest‐machine‐learning‐models, we studied if the metabolic‐profile at 3 months can predict body composition outcomes at 2 years of age. Results: Plasma metabolite‐profile at 3 months was found to predict body composition at 2 years, based on truncal: peripheral‐fat‐skinfold‐ratio (T:P‐ratio), with a predictive value of 75.8%, sensitivity of 100% and specificity of 50%. Predictive value was higher in boys (Q2 = 0.322) than girls (Q2 = 0.117). Of the 15 metabolite variables most strongly associated with T:P‐ratio, 11 were also associated with visceral fat at 2 years of age. Conclusion: Several plasma metabolites (LysoPC(22:2), dimethylarginine and others) at 3 months associate with body composition outcome at 2 years. These results highlight the importance of the first months of life for adiposity programming.
dc.languageen
dc.publisherJohn Wiley & Sons, Inc.
dc.subjectORIGINAL RESEARCH
dc.subjectadiposity
dc.subjectbody composition
dc.subjectinfants
dc.subjectmetabolomics
dc.subjectskinfolds
dc.titleMetabolomics in early life and the association with body composition at age 2 years
dc.typeArticle
dc.date.updated2021-10-14T01:29:41Z
prism.publicationNamePediatric Obesity
dc.identifier.doi10.17863/CAM.76842
dcterms.dateAccepted2021-09-20
rioxxterms.versionofrecord10.1111/ijpo.12859
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidvan Beijsterveldt, Inge A.L.P. [0000-0002-0204-7430]
dc.contributor.orcidde Fluiter, Kirsten S. [0000-0002-5848-7929]
dc.contributor.orcidKoulman, Albert [0000-0001-9998-051X]
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/P028195/1)
pubs.funder-project-idEU Commission ‐ JPI HDHL program (696295)
pubs.funder-project-idInnovationsfonden (4203‐00005B)
pubs.funder-project-idMedical Research Council (MC_UU_00006/2)
pubs.funder-project-idNIHR Cambridge Biomedical Research Centre (146281)
pubs.funder-project-idZonMw (529051013)


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