Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior.
Slob, Eric AW
Koellinger, Philipp D
Springer Science and Business Media LLC
MetadataShow full item record
de Vlaming, R., Slob, E. A., Jansen, P. R., Dagher, A., Koellinger, P. D., Groenen, P. J., & Rietveld, C. A. (2021). Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior.. Commun Biol, 4 (1), 1180. https://doi.org/10.1038/s42003-021-02712-y
Human variation in brain morphology and behavior are related and highly heritable. Yet, it is largely unknown to what extent specific features of brain morphology and behavior are genetically related. Here, we introduce a computationally efficient approach for multivariate genomic-relatedness-based restricted maximum likelihood (MGREML) to estimate the genetic correlation between a large number of phenotypes simultaneously. Using individual-level data (N = 20,190) from the UK Biobank, we provide estimates of the heritability of gray-matter volume in 74 regions of interest (ROIs) in the brain and we map genetic correlations between these ROIs and health-relevant behavioral outcomes, including intelligence. We find four genetically distinct clusters in the brain that are aligned with standard anatomical subdivision in neuroscience. Behavioral traits have distinct genetic correlations with brain morphology which suggests trait-specific relevance of ROIs. These empirical results illustrate how MGREML can be used to estimate internally consistent and high-dimensional genetic correlation matrices in large datasets.
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
External DOI: https://doi.org/10.1038/s42003-021-02712-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329436
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/