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dc.contributor.authorCallingham, Brian A
dc.contributor.authorKhan, M Akram
dc.contributor.authorMilton, Anthony S
dc.contributor.authorRainsford, KD
dc.date.accessioned2021-10-18T08:42:26Z
dc.date.available2021-10-18T08:42:26Z
dc.date.issued2021-10
dc.date.submitted2021-07-02
dc.identifier.issn0925-4692
dc.identifier.others10787-021-00858-z
dc.identifier.other858
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329484
dc.descriptionFunder: University of Cambridge
dc.description.abstractBACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are a major cause of upper gastro-intestinal (GI) ulceration and bleeding as well as cardiovascular (CV) diseases (e.g., myocardial infarction and stroke). A feature common to both these adverse events is a variety of vascular reactions. One approach to overcome these side effects has been the development of nitric-oxide (NO)-donating NSAIDs. The NO is considered to overcome some of these vascular reactions caused by NSAIDs. Unfortunately, the NO-NSAIDs developed so far have not had the expected benefits compared with NSAIDs alone. OBJECTIVES: Using in vitro preparations it is hoped to gain insight into the vascular and smooth muscle reactions induced by NO-NSAIDs compared with NSAIDs as a basis for improving the protective responses attributed to the NO-donating properties of these drugs. METHODS: A range of NO-NSAIDs was synthesized based on the esterification of NSAIDs with the nitro-butoxylate as a prototype of an NO-donor. These compounds, as well as NO-donor agents and NSAIDS, were examined for their possible effects on isolated segments of digital arteries of fallow deer, which provide a robust model for determining the effects of vasodilator and vasoconstrictor activities, in comparison with those of standard pharmacological agents. RESULTS: The NO-NSAIDs were found to antagonise the smooth muscle contractions produced by 5-hydroxytryptamine (serotonin, 5-HT). However, while almost all their parent NSAIDs had little or no effect, with the exception of the R-(-)-isomers of both ibuprofen and flurbiprofen, which caused vasodilatation, all the NO-NSAIDs tested antagonised the increase in tension produced by 5-HT. CONCLUSIONS: R-(-)-ibuprofen and R-(-)-flurbiprofen, along with the nitro-butoxyl esters of the NSAIDs examined, produce relaxation of segments of deer digital artery smooth muscle in vitro. The evidence presented suggests that their mechanism involves the release of NO or its products.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectOriginal Article
dc.subjectNSAIDs
dc.subjectNitric oxide
dc.subjectArterial
dc.subjectDeer
dc.subjectSmooth muscle
dc.subjectGastrointestinal
dc.subjectCardiovascular
dc.subjectNO-NSAIDs
dc.titleEffects of nitro-butoxyl- and butyl-esters of non-steroidal anti-inflammatory drugs compared with parent compounds on the contractility of digital arterial smooth muscle from the fallow deer (Dama dama).
dc.typeArticle
dc.date.updated2021-10-18T08:42:25Z
prism.endingPage1473
prism.issueIdentifier5
prism.publicationNameInflammopharmacology
prism.startingPage1459
prism.volume29
dc.identifier.doi10.17863/CAM.76932
dcterms.dateAccepted2021-07-26
rioxxterms.versionofrecord10.1007/s10787-021-00858-z
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1568-5608
cam.issuedOnline2021-09-16


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