Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway
Authors
Luo, Qiang
Zhang, Lingli
Huang, Chu-Chung
Zheng, Yan
Kanen, Jonathan W.
Zhao, Qi
Yao, Ye
Quinlan, Erin B.
Jia, Tianye
Banaschewski, Tobias
Bokde, Arun L. W.
Bromberg, Uli
Büchel, Christian
Flor, Herta
Frouin, Vincent
Garavan, Hugh
Gowland, Penny
Heinz, Andreas
Ittermann, Bernd
Martinot, Jean-Luc
Martinot, Marie-Laure Paillère
Nees, Frauke
Orfanos, Dimitri Papadopoulos
Poustka, Luise
Hohmann, Sarah
Fröhner, Juliane H.
Smolka, Michael N.
Walter, Henrik
Whelan, Robert
Sahakian, Barbara J.
Schumann, Gunter
Li, Fei
Feng, Jianfeng
Desrivières, Sylvane
Robbins, Trevor W.
Publication Date
2020-10-15Journal Title
BMC Medicine
Publisher
BioMed Central
Volume
18
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Luo, Q., Zhang, L., Huang, C., Zheng, Y., Kanen, J. W., Zhao, Q., Yao, Y., et al. (2020). Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway. BMC Medicine, 18 (1) https://doi.org/10.1186/s12916-020-01743-2
Description
Funder: Zhangjiang Lab
Funder: the Shanghai AI Platform for Diagnosis and Treatment of Brain Diseases
Funder: the Project of Zhangjiang Hi-Tech District Management Committee
Funder: Shanghai (grant 2016-17)
Funder: BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics); Grant(s): MR/N027558/1
Funder: Associazione Emma e Ernesto Rulfo per la Genetica Medica (IT)
Funder: the Swedish Research Council FORMAS
Funder: the Medical Research Council
Funder: the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London
Funder: the Human Brain Project (HBP SGA 2)
Funder: the Fondation de France, the Fondation pour la Recherche Médicale
Funder: the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant)
Funder: Paris Sud University IDEX 2012
Funder: cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence
Abstract
Abstract: Background: Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined. Methods: Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the findings was performed in the UKB. White-matter connectivity analysis was conducted to study the structural connectivity between the identified brain region and subdivisions of the hypothalamus in the HCP. Results: In IMAGEN, a smaller frontopolar cortex (FPC) was associated with both childhood abuse (CA) (β = − .568, 95%CI − .942 to − .194; p = .003) and higher BMI (β = − .086, 95%CI − .128 to − .043; p < .001) in male participants, and these findings were validated in UKB. Across seven data collection sites, a stronger negative CA-FPC association was correlated with a higher positive CA-BMI association (β = − 1.033, 95%CI − 1.762 to − .305; p = .015). Using 7-T diffusion tensor imaging data (n = 156), we found that FPC was the third most connected cortical area with the hypothalamus, especially the lateral hypothalamus. A smaller FPC at age 14 contributed to higher BMI at age 19 in those male participants with a history of CA, and the CA-FPC interaction enabled a model at age 14 to account for some future weight gain during a 5-year follow-up (variance explained 5.8%). Conclusions: The findings highlight that a malfunctioning, top-down cognitive or behavioral control system, independent of genetic predisposition, putatively contributes to excessive weight gain in a particularly vulnerable population, and may inform treatment approaches.
Keywords
Research Article, Childhood trauma, Adult obesity, Neurocognitive control pathway, Structural brain imaging
Sponsorship
National Key Research and Development Program of China (2018YFC0910503)
National Natural Science Foundation of China (81873909)
Natural Science Foundation of Shanghai (17ZR1444400)
Shanghai Municipal Science and Technology Major Project (2018SHZDZX01)
National Natural Science Foundation of China (81571031, 81761128035, and 81930095)
Shanghai Municipal Commission of Health and Family Planning (2017ZZ02026, 2018BR33, 2017EKHWYX-02 and GDEK201709)
Shanghai Shenkang Hospital Development (16CR2025B)
Shanghai Municipal Education Commission (20152234)
Shanghai Committee of Science and Technology (17XD1403200, 19410713500, and 18DZ2313505)
Key projects of Guangdong Province (2018B030335001)
Xinhua Hospital of Shanghai Jiao Tong University School of Medicine (Xinhua Hospital of Shanghai Jiao Tong University School of Medicine)
key project of Shanghai Science and Technology Innovation Plan (16JC1420402)
the National Natural Science Foundation of China (91630314)
111 project (B18015)
the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behaviour in normal brain function and psychopathology) (LSHM-CT-2007-037286)
the Horizon 2020 funded ERC Advanced Grant ‘STRATIFY’ (Brain network based stratification of reinforcement-related disorders) (695313)
ERANID (Understanding the Interplay between Cultural, Biological and Subjective Factors in Drug Use Pathways) (PR-ST-0416-10004)
MATRICS (603016)
the Innovative Medicine Initiative Project EU-AIMS (115300-2)
the Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1)
the Bundesministeriumfür Bildung und Forschung (BMBF grants 01GS08152)
the Deutsche Forschungsgemeinschaft (DFG grants SM 80/7-2, SFB 940/2)
the Medical Research Foundation and Medical research council (MR/R00465X/1)
ANR (project AF12-NEUR0008-01 - WM2NA, and ANR-12-SAMA-0004)
the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA)
the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797)
U.S.A. (Axon, Testosterone and Mental Health during Adolescence) (RO1 MH085772-01A1)
NIH Consortium grant (U54 EB020403)
National Key R&D Program of China (2019YFA0709502)
Identifiers
s12916-020-01743-2, 1743
External DOI: https://doi.org/10.1186/s12916-020-01743-2
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329500
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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