Show simple item record

dc.contributor.authorKariuki, Samuel
dc.contributor.authorDyson, Zoe A
dc.contributor.authorMbae, Cecilia
dc.contributor.authorNgetich, Ronald
dc.contributor.authorKavai, Susan M
dc.contributor.authorWairimu, Celestine
dc.contributor.authorAnyona, Stephen
dc.contributor.authorGitau, Naomi
dc.contributor.authorOnsare, Robert Sanaya
dc.contributor.authorOngandi, Beatrice
dc.contributor.authorDuchene, Sebastian
dc.contributor.authorAli, Mohamed
dc.contributor.authorClemens, John David
dc.contributor.authorHolt, Kathryn E
dc.contributor.authorDougan, Gordon
dc.date.accessioned2021-10-18T08:47:38Z
dc.date.available2021-10-18T08:47:38Z
dc.date.issued2021-09-13
dc.identifier.issn2050-084X
dc.identifier.otherPMC8494480
dc.identifier.other34515028
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329525
dc.description.abstract<h4>Background</h4>Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control.<h4>Methods</h4>In a 3-year case-control study, we investigated typhoid among children aged <16 years (4670 febrile cases and 8549 age matched controls) living in an informal settlement, Nairobi, Kenya.<h4>Results</h4>148 <i>S</i>. Typhi isolates from cases and 95 from controls (stool culture) were identified; a carriage frequency of 1 %. Whole-genome sequencing showed 97% of cases and 88% of controls were genotype 4.3.1 (Haplotype 58), with the majority of each (76% and 88%) being multidrug-resistant strains in three sublineages of the H58 genotype (East Africa 1 (EA1), EA2, and EA3), with sequences from cases and carriers intermingled.<h4>Conclusions</h4>The high rate of multidrug-resistant H58 <i>S</i>. Typhi, and the close phylogenetic relationships between cases and controls, provides evidence for the role of carriers as a reservoir for the community spread of typhoid in this setting.<h4>Funding</h4>National Institutes of Health (R01AI099525); Wellcome Trust (106158/Z/14/Z); European Commission (TyphiNET No 845681); National Institute for Health Research (NIHR); Bill and Melinda Gates Foundation (OPP1175797).
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2050-084X
dc.sourcenlmid: 101579614
dc.subjectMicrobiology
dc.subjectChildren
dc.subjectInfectious disease
dc.subjectepidemiology
dc.subjectKenya
dc.subjectTyphoid
dc.subjectGlobal Health
dc.subjectCarriage
dc.subjectMultidrug-resistant
dc.subjectS. Enterica Serovar Typhi
dc.subjectH58 Lineages
dc.titleMultiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya.
dc.typeArticle
dc.date.updated2021-10-18T08:47:37Z
prism.publicationNameeLife
prism.volume10
dc.identifier.doi10.17863/CAM.76973
rioxxterms.versionofrecord10.7554/elife.67852
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidKariuki, Samuel [0000-0003-3209-9503]
dc.contributor.orcidDyson, Zoe A [0000-0002-8887-3492]
pubs.funder-project-idNIAID NIH HHS (R01 AI099525)
pubs.funder-project-idBill and Melinda Gates Foundation (OPP1175797)
pubs.funder-project-idDepartment of Health (AMR Theme)
pubs.funder-project-idEuropean Commission (TyphiNET No 845681)
pubs.funder-project-idNational Institutes of Health (R01AI099525)
pubs.funder-project-idWellcome Trust (106158/Z/14/Z)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International