Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves
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Authors
Tarotin, Ilya
Donega, Matteo
Ouchouche, Sebastien
Dopson, Wesley
Matteucci, Paul
Schiefer, Matthew A.
Rowles, Alison
McGill, Paul
Perkins, Justin
Kuster, Niels
Yazicioglu, Refet Firat
Witherington, Jason
Publication Date
2020-10-16Journal Title
Communications Biology
Publisher
Nature Publishing Group UK
Volume
3
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Gupta, I., Cassará, A. M., Tarotin, I., Donega, M., Miranda, J. A., Sokal, D. M., Ouchouche, S., et al. (2020). Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves. Communications Biology, 3 (1) https://doi.org/10.1038/s42003-020-01299-0
Abstract
Abstract: Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of the autonomic connections to the spleen. However, targeting this sub-division of the nervous system presents specific challenges in translating nerve stimulation parameters. Firstly, autonomic nerves are typically embedded non-uniformly among visceral and connective tissues with complex interfacing requirements. Secondly, these nerves contain axons with populations of varying phenotypes leading to complexities for axon engagement and activation. Thirdly, clinical translational of methodologies attained using preclinical animal models are limited due to heterogeneity of the intra- and inter-species comparative anatomy and physiology. Here we demonstrate how this can be accomplished by the use of in silico modelling of target anatomy, and validation of these estimations through ex vivo human tissue electrophysiology studies. Neuroelectrical models are developed to address the challenges in translation of parameters, which provides strong input criteria for device design and dose selection prior to a first-in-human trial.
Keywords
Article, /631/1647/1453, /692/308/575, /631/114/2397, /14/28, /9/30, article
Identifiers
s42003-020-01299-0, 1299
External DOI: https://doi.org/10.1038/s42003-020-01299-0
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329536
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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