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dc.contributor.authorSerrao, Eva M.
dc.contributor.authorKessler, Dimitri A.
dc.contributor.authorCarmo, Bruno
dc.contributor.authorBeer, Lucian
dc.contributor.authorBrindle, Kevin M.
dc.contributor.authorBuonincontri, Guido
dc.contributor.authorGallagher, Ferdia A.
dc.contributor.authorGilbert, Fiona J.
dc.contributor.authorGodfrey, Edmund
dc.contributor.authorGraves, Martin J.
dc.contributor.authorMcLean, Mary A.
dc.contributor.authorSala, Evis
dc.contributor.authorSchulte, Rolf F.
dc.contributor.authorKaggie, Joshua D.
dc.date.accessioned2021-10-18T08:50:07Z
dc.date.available2021-10-18T08:50:07Z
dc.date.issued2020-10-16
dc.date.submitted2020-04-08
dc.identifier.others41598-020-74462-6
dc.identifier.other74462
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329544
dc.descriptionFunder: GlaxoSmithKline; doi: http://dx.doi.org/10.13039/100004330
dc.descriptionFunder: National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre
dc.descriptionFunder: Addenbrooke's Charitable Trust, Cambridge University Hospitals; doi: http://dx.doi.org/10.13039/501100002927
dc.description.abstractAbstract: Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation of pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time constraints and motion sensitivity. MR Fingerprinting is an innovative acquisition technique that provides qualitative data and quantitative parameter maps from a single free‐breathing acquisition with the potential to reduce exam times. This work investigates the feasibility of MRF parameter mapping for pancreatic imaging in the presence of free-breathing exam. Sixteen healthy participants were prospectively imaged using MRF framework. Regions-of-interest were drawn in multiple solid organs including the pancreas and T1 and T2 values determined. MRF T1 and T2 mapping was performed successfully in all participants (acquisition time:2.4–3.6 min). Mean pancreatic T1 values were 37–43% lower than those of the muscle, spleen, and kidney at both 1.5 and 3.0 T. For these organs, the mean pancreatic T2 values were nearly 40% at 1.5 T and < 12% at 3.0 T. The feasibility of MRF at 1.5 T and 3 T was demonstrated in the pancreas. By enabling fast and free-breathing quantitation, MRF has the potential to add value during the clinical characterisation and grading of pathological conditions, such as pancreatitis or cancer.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/692/308/53/2421
dc.subject/692/700/1421
dc.subjectarticle
dc.titleMagnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T
dc.typeArticle
dc.date.updated2021-10-18T08:50:06Z
prism.issueIdentifier1
prism.publicationNameScientific Reports
prism.volume10
dc.identifier.doi10.17863/CAM.76992
dcterms.dateAccepted2020-09-29
rioxxterms.versionofrecord10.1038/s41598-020-74462-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2045-2322
pubs.funder-project-idCancer Research UK Cambridge Centre (CA685/A25177, CA685/A25177, CA685/A25177, CA685/A25177, CA685/A25177, CA685/A25177)
pubs.funder-project-idHorizon 2020 Framework Programme (761214)


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