Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19.
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Authors
Blundell, Tom L
Moreno, Pablo
Publication Date
2021-10Journal Title
Life Sci Alliance
ISSN
2575-1077
Publisher
Life Science Alliance, LLC
Volume
4
Issue
10
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic-Print
Metadata
Show full item recordCitation
Bannerman, B. P., Júlvez, J., Oarga, A., Blundell, T. L., Moreno, P., & Floto, R. A. (2021). Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19.. Life Sci Alliance, 4 (10) https://doi.org/10.26508/lsa.202000954
Abstract
The coronavirus disease 2019 (COVID-19) pandemic caused by the new coronavirus (SARS-CoV-2) is currently responsible for more than 3 million deaths in 219 countries across the world and with more than 140 million cases. The absence of FDA-approved drugs against SARS-CoV-2 has highlighted an urgent need to design new drugs. We developed an integrated model of the human cell and SARS-CoV-2 to provide insight into the virus' pathogenic mechanism and support current therapeutic strategies. We show the biochemical reactions required for the growth and general maintenance of the human cell, first, in its healthy state. We then demonstrate how the entry of SARS-CoV-2 into the human cell causes biochemical and structural changes, leading to a change of cell functions or cell death. A new computational method that predicts 20 unique reactions as drug targets from our models and provides a platform for future studies on viral entry inhibition, immune regulation, and drug optimisation strategies. The model is available in BioModels (https://www.ebi.ac.uk/biomodels/MODEL2007210001) and the software tool, findCPcli, that implements the computational method is available at https://github.com/findCP/findCPcli.
Keywords
Humans, Drug Evaluation, Preclinical, Computational Biology, Models, Biological, Pandemics, Drug Development, COVID-19, SARS-CoV-2
Sponsorship
Wellcome Trust (107032/B/15/Z)
Identifiers
External DOI: https://doi.org/10.26508/lsa.202000954
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329594
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