Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa.

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Authors
Ahuno, Samuel Terkper
  Doebley, Anna-Lisa
Ahearn, Thomas U
Yarney, Joel
Titiloye, Nicholas
Hamel, Nancy
Adjei, Ernest
Publication Date
2021-09-17
Journal Title
NPJ Precis Oncol
ISSN
2397-768X
Publisher
Springer Science and Business Media LLC
Volume
5
Issue
1
Pages
83
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic
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Citation
Ahuno, S. T., Doebley, A., Ahearn, T. U., Yarney, J., Titiloye, N., Hamel, N., Adjei, E., et al. (2021). Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa.. NPJ Precis Oncol, 5 (1), 83. https://doi.org/10.1038/s41698-021-00219-7
Abstract
Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.
Keywords
Ghana Breast Health Study Team
Identifiers
External DOI: https://doi.org/10.1038/s41698-021-00219-7
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329638
Rights
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International