Enhancing the spatial resolution of hyperpolarized carbon-13 MRI of human brain metabolism using structure guidance.
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Publication Date
2022-03Journal Title
Magn Reson Med
ISSN
0740-3194
Publisher
Wiley
Language
eng
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Ehrhardt, M. J., Gallagher, F. A., McLean, M. A., & Schönlieb, C. (2022). Enhancing the spatial resolution of hyperpolarized carbon-13 MRI of human brain metabolism using structure guidance.. Magn Reson Med https://doi.org/10.1002/mrm.29045
Abstract
PURPOSE: Dynamic nuclear polarization is an emerging imaging method that allows noninvasive investigation of tissue metabolism. However, the relatively low metabolic spatial resolution that can be achieved limits some applications, and improving this resolution could have important implications for the technique. METHODS: We propose to enhance the 3D resolution of carbon-13 magnetic resonance imaging (13 C-MRI) using the structural information provided by hydrogen-1 MRI (1 H-MRI). The proposed approach relies on variational regularization in 3D with a directional total variation regularizer, resulting in a convex optimization problem which is robust with respect to the parameters and can efficiently be solved by many standard optimization algorithms. Validation was carried out using an in silico phantom, an in vitro phantom and in vivo data from four human volunteers. RESULTS: The clinical data used in this study were upsampled by a factor of 4 in-plane and by a factor of 15 out-of-plane, thereby revealing occult information. A key finding is that 3D super-resolution shows superior performance compared to several 2D super-resolution approaches: for example, for the in silico data, the mean-squared-error was reduced by around 40% and for all data produced increased anatomical definition of the metabolic imaging. CONCLUSION: The proposed approach generates images with enhanced anatomical resolution while largely preserving the quantitative measurements of metabolism. Although the work requires clinical validation against tissue measures of metabolism, it offers great potential in the field of 13 C-MRI and could significantly improve image quality in the future.
Keywords
human brain, hyperpolarized 13C, magnetic resonance imaging, super-resolution, variational regularization
Sponsorship
Mark Foundation Institute for Cancer Research
Leverhulme Trust ECF‐2019‐478 Philip Leverhulme Prize
Wellcome Trust RG98755
Royal Society Wolfson Fellowship
Cambridge Experimental Cancer Medicine Centre
Alan Turing Institute
Cantab Capital Institute for the Mathematics of Information
H2020 European Research Council 777826
National Institute for Health Research Cambridge Biomedical Research Centre
Cancer Research UK C19212/A16628 C19212/A911376 C19212/A27150 C968
Engineering and Physical Sciences Research Council EP/S026045/1 EP/T026693/1 EP/T007745/1 EP/T0035
Funder references
Cancer Research UK (unknown)
Cancer Research UK (C14303/A17197)
Cancer Research UK (C12912/A27150)
Cancer Research UK (C19212/A29082)
EPSRC (EP/S026045/1)
Identifiers
External DOI: https://doi.org/10.1002/mrm.29045
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329650
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http://www.rioxx.net/licenses/all-rights-reserved
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