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dc.contributor.authorCarrick, Frederick Robert
dc.contributor.authorAzzolino, Sergio F
dc.contributor.authorHunfalvay, Melissa
dc.contributor.authorPagnacco, Guido
dc.contributor.authorOggero, Elena
dc.contributor.authorD'Arcy, Ryan CN
dc.contributor.authorAbdulrahman, Mahera
dc.contributor.authorSugaya, Kiminobu
dc.date.accessioned2021-10-20T00:15:55Z
dc.date.available2021-10-20T00:15:55Z
dc.date.issued2021-10-18
dc.identifier.issn2075-1729
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329655
dc.description.abstractThe size of our pupils changes continuously in response to variations in ambient light levels, a process known as the pupillary light reflex (PLR). The PLR is not a simple reflex as its function is modulated by cognitive brain function and any long-term changes in brain function secondary to injury should cause a change in the parameters of the PLR. We performed a retrospective clinical review of the PLR of our patients using the BrightLamp Reflex iPhone app. The PLR variables of latency, maximum pupil diameter (MaxPD), minimum pupil diameter (MinPD), maximum constriction velocity (MCV), and the 75% recovery time (75% PRT) were associated with significant differences between subjects who had suffered a concussion and those that had not. There were also significant differences in PLR metrics over the life span and between genders and those subjects with and without symptoms. The differences in PLR metrics are modulated not only by concussion history but also by gender and whether or not the person has symptoms associated with a head injury. A concussive injury to the brain is associated with changes in the PLR that persist over the life span, representing biomarkers that might be used in clinical diagnosis, treatment, and decision making.
dc.languageen
dc.publisherMDPI AG
dc.subjectpupil light reflex
dc.subjectconcussion
dc.subjectgender difference
dc.subjectbrain function
dc.subjectpupillometry
dc.titleThe Pupillary Light Reflex as a Biomarker of Concussion.
dc.typeArticle
dc.date.updated2021-10-20T00:15:55Z
prism.issueIdentifier10
prism.publicationNameLife (Basel)
prism.volume11
dc.identifier.doi10.17863/CAM.77104
dcterms.dateAccepted2021-10-12
rioxxterms.versionofrecord10.3390/life11101104
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidCarrick, Frederick Robert [0000-0002-2818-6551]
dc.contributor.orcidAbdulrahman, Mahera [0000-0001-6271-3776]
dc.contributor.orcidSugaya, Kiminobu [0000-0002-2788-5457]
dc.identifier.eissn2075-1729
cam.issuedOnline2021-10-18


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