Implications of mitochondrial DNA mutations in human induced pluripotent stem cells.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Carelli, Valerio
Hirano, Michio
Enríquez, José Antonio https://orcid.org/0000-0002-3671-2961
Chinnery, Patrick F https://orcid.org/0000-0002-7065-6617
Abstract
Single-cell analyses in recent years have shown major differences in the transcriptome between individual cells in the same induced pluripotent stem cell-derived clones. Although these differences are in part attributable to genetic and epigenetic modifications of the nuclear genome, emerging evidence suggests that variants in mitochondrial DNA also play a pivotal role.
Description
Keywords
Aging, Cell Line, Cells, Cultured, Cellular Reprogramming, Clone Cells, DNA, Mitochondrial, Energy Metabolism, Humans, Induced Pluripotent Stem Cells, Mitochondria, Mutation, Single-Cell Analysis
Journal Title
Nat Rev Genet
Conference Name
Journal ISSN
1471-0056
1471-0064
1471-0064
Volume Title
Publisher
Springer Science and Business Media LLC
Publisher DOI
Rights
Sponsorship
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Wellcome Trust (212219/Z/18/Z)
National Institute for Health and Care Research (IS-BRC-1215-20014)
MRC (MR/S035699/1)
Engineering and Physical Sciences Research Council (EP/N01426X/1)
Medical Research Council (MC_UU_00015/7)
Wellcome Trust (212219/Z/18/Z)
National Institute for Health and Care Research (IS-BRC-1215-20014)
MRC (MR/S035699/1)
Engineering and Physical Sciences Research Council (EP/N01426X/1)
Medical Research Council (MC_UU_00015/7)