Implications of mitochondrial DNA mutations in human induced pluripotent stem cells.
Nat Rev Genet
Springer Science and Business Media LLC
MetadataShow full item record
Carelli, V., Hirano, M., Enríquez, J. A., & Chinnery, P. F. (2022). Implications of mitochondrial DNA mutations in human induced pluripotent stem cells.. Nat Rev Genet https://doi.org/10.1038/s41576-021-00430-z
Single-cell analyses in recent years have shown major differences in the transcriptome between individual cells in the same induced pluripotent stem cell-derived clones. Although these differences are in part attributable to genetic and epigenetic modifications of the nuclear genome, emerging evidence suggests that variants in mitochondrial DNA also play a pivotal role.
Aging, Cell Line, Cells, Cultured, Cellular Reprogramming, Clone Cells, DNA, Mitochondrial, Energy Metabolism, Humans, Induced Pluripotent Stem Cells, Mitochondria, Mutation, Single-Cell Analysis
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Wellcome Trust (212219/Z/18/Z)
National Institute for Health Research (IS-BRC-1215-20014)
External DOI: https://doi.org/10.1038/s41576-021-00430-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329735
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