Implications of mitochondrial DNA mutations in human induced pluripotent stem cells.
Nat Rev Genet
Springer Science and Business Media LLC
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Carelli, V., Hirano, M., Enríquez, J. A., & Chinnery, P. (2022). Implications of mitochondrial DNA mutations in human induced pluripotent stem cells.. Nat Rev Genet https://doi.org/10.1038/s41576-021-00430-z
Single-cell analyses in recent years have shown major differences in the transcriptome between individual cells in the same induced pluripotent stem cell-derived clones. Although these differences are in part attributable to genetic and epigenetic modifications of the nuclear genome, emerging evidence suggests that variants in mitochondrial DNA also play a pivotal role.
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Wellcome Trust (212219/Z/18/Z)
National Institute for Health Research (NIHRDH-IS-BRC-1215-20014)
External DOI: https://doi.org/10.1038/s41576-021-00430-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329735
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