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dc.contributor.authorMaeda, Kota
dc.contributor.authorSadoughi, Sonya
dc.contributor.authorMorimoto, Ayako
dc.contributor.authorUchida, Kazuyuki
dc.contributor.authorChambers, James K
dc.contributor.authorSanjoba, Chizu
dc.contributor.authorYamagishi, Junya
dc.contributor.authorGoto, Yasuyuki
dc.date.accessioned2021-10-22T02:09:10Z
dc.date.available2021-10-22T02:09:10Z
dc.date.issued2021-10-20
dc.identifier.issn2076-0817
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329754
dc.description.abstractVisceral leishmaniasis (VL) is the most severe form of leishmaniasis caused by protozoan parasites of the genus Leishmania. Hepatomegaly is one of the most frequent clinical manifestations of VL, whereas immunopathology of the symptom has not been well investigated. Using our chronic model of experimental VL, we examined the influence of Leishmania donovani infection on the liver by clinical, histological, and biochemical analyses. The infected mice showed increased liver weight 24 weeks post-infection. Although an increase in serum ALT and inflammatory cell accumulation were observed in the livers of infected mice, no apparent parenchymal necrosis or fibrosis was observed. Tissue water content analyses demonstrated that increased liver weight was predominantly due to an increase in water weight. Together with the finding of hepatic sinusoidal dilation, these results suggested that edema associated with sinusoidal dilation causes hepatomegaly in L. donovani infection. Immunostaining of platelets and erythrocytes showed no thrombus formation or damage to the sinusoidal endothelium in the liver of infected mice. Taken together, these results suggest that hepatomegaly during experimental VL is caused by non-obstructive sinusoidal dilation.
dc.languageen
dc.publisherMDPI AG
dc.subjectvisceral leishmaniasis
dc.subjecthepatomegaly
dc.subjectsinusoid
dc.subjectedema
dc.titleHepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis.
dc.typeArticle
dc.date.updated2021-10-22T02:09:10Z
prism.issueIdentifier11
prism.publicationNamePathogens
prism.volume10
dc.identifier.doi10.17863/CAM.77200
dcterms.dateAccepted2021-10-18
rioxxterms.versionofrecord10.3390/pathogens10111356
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2076-0817
pubs.funder-project-idJapan Society for the Promotion of Science (18H02649, 20K21516, 21H02722)
cam.issuedOnline2021-10-20


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