Photocatalytic C-H Azolation of Arenes Using Heterogeneous Carbon Nitride in Batch and Flow.
Authors
Wen, Zhenghui
Wan, Ting
Vijeta, Arjun
Casadevall, Carla
Buglioni, Laura
Noël, Timothy
Publication Date
2021-12-06Journal Title
ChemSusChem
ISSN
1864-5631
Publisher
Wiley
Language
en
Type
Article
This Version
AO
VoR
Metadata
Show full item recordCitation
Wen, Z., Wan, T., Vijeta, A., Casadevall, C., Buglioni, L., Reisner, E., & Noël, T. (2021). Photocatalytic C-H Azolation of Arenes Using Heterogeneous Carbon Nitride in Batch and Flow.. ChemSusChem https://doi.org/10.1002/cssc.202101767
Description
Funder: China Scholarship Council (CSC)
Funder: Cambridge Trust and Science and Engineering Research Board (SERB) India
Funder: University of Cambridge; Id: http://dx.doi.org/10.13039/501100000735
Abstract
The functionalization of aryl C(sp2 )-H bonds is a useful strategy for the late-stage modification of biologically active molecules, especially for the regioselective introduction of azole heterocycles to prepare medicinally-relevant compounds. Herein, we describe a practical photocatalytic transformation using a mesoporous carbon nitride (mpg-CNx ) photocatalyst, which enables the efficient azolation of various arenes through direct oxidation. The method exhibits a broad substrate scope and is amenable to the late-stage functionalization of several pharmaceuticals. Due to the heterogeneous nature and high photocatalytic stability of mpg-CNx , the catalyst can be easily recovered and reused leading to greener and more sustainable routes, using either batch or flow processing, to prepare these important compounds of interest in pharmaceutical and agrochemical research.
Keywords
azolation, carbon nitride, flow chemistry, heterogeneous catalysis, photocatalysis
Sponsorship
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (890745)
Engineering and Physical Sciences Research Council (EP/P030467/1)
Identifiers
cssc202101767
External DOI: https://doi.org/10.1002/cssc.202101767
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329763
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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