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Photocatalytic C-H Azolation of Arenes Using Heterogeneous Carbon Nitride in Batch and Flow.

Published version
Peer-reviewed

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Authors

Wen, Zhenghui 
Wan, Ting 
Vijeta, Arjun 
Casadevall, Carla 
Buglioni, Laura 

Abstract

The functionalization of aryl C(sp2 )-H bonds is a useful strategy for the late-stage modification of biologically active molecules, especially for the regioselective introduction of azole heterocycles to prepare medicinally-relevant compounds. Herein, we describe a practical photocatalytic transformation using a mesoporous carbon nitride (mpg-CNx ) photocatalyst, which enables the efficient azolation of various arenes through direct oxidation. The method exhibits a broad substrate scope and is amenable to the late-stage functionalization of several pharmaceuticals. Due to the heterogeneous nature and high photocatalytic stability of mpg-CNx , the catalyst can be easily recovered and reused leading to greener and more sustainable routes, using either batch or flow processing, to prepare these important compounds of interest in pharmaceutical and agrochemical research.

Description

Funder: China Scholarship Council (CSC)


Funder: Cambridge Trust and Science and Engineering Research Board (SERB) India


Funder: University of Cambridge; Id: http://dx.doi.org/10.13039/501100000735

Keywords

azolation, carbon nitride, flow chemistry, heterogeneous catalysis, photocatalysis

Journal Title

ChemSusChem

Conference Name

Journal ISSN

1864-5631
1864-564X

Volume Title

Publisher

Wiley
Sponsorship
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (890745)
Engineering and Physical Sciences Research Council (EP/P030467/1)