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dc.contributor.authorThomas, Luke W
dc.contributor.authorAshcroft, Margaret
dc.date.accessioned2021-10-22T23:30:35Z
dc.date.available2021-10-22T23:30:35Z
dc.date.issued2021
dc.identifier.issn2296-634X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329799
dc.description.abstractMitochondria are key organelles in eukaryotic evolution that perform crucial roles as metabolic and cellular signaling hubs. Mitochondrial function and dysfunction are associated with a range of diseases, including cancer. Mitochondria support cancer cell proliferation through biosynthetic reactions and their role in signaling, and can also promote tumorigenesis via processes such as the production of reactive oxygen species (ROS). The advent of (nuclear) genome-wide CRISPR-Cas9 deletion screens has provided gene-level resolution of the requirement of nuclear-encoded mitochondrial genes (NEMGs) for cancer cell viability (essentiality). More recently, it has become apparent that the essentiality of NEMGs is highly dependent on the cancer cell context. In particular, key tumor microenvironmental factors such as hypoxia, and changes in nutrient (e.g., glucose) availability, significantly influence the essentiality of NEMGs. In this mini-review we will discuss recent advances in our understanding of the contribution of NEMGs to cancer from CRISPR-Cas9 deletion screens, and discuss emerging concepts surrounding the context-dependent nature of mitochondrial gene essentiality.
dc.description.sponsorshipLWT was funded by the Wellcome Trust (grant RG93172), Isaac Newton Trust [grant 21.07(b)] and Cancer Research UK Cambridge Cancer Centre funding awarded to MA.
dc.languageeng
dc.publisherFrontiers Media SA
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectessentiality
dc.subjectmetabolism
dc.subjectmitochondria
dc.subjectsignaling
dc.subjectviability
dc.titleThe Contextual Essentiality of Mitochondrial Genes in Cancer.
dc.typeArticle
prism.publicationDate2021
prism.publicationNameFront Cell Dev Biol
prism.startingPage695351
prism.volume9
dc.identifier.doi10.17863/CAM.77244
dcterms.dateAccepted2021-10-05
rioxxterms.versionofrecord10.3389/fcell.2021.695351
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021
dc.contributor.orcidAshcroft, Margaret [0000-0002-0066-3707]
dc.identifier.eissn2296-634X
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-10-22


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International