Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying.
Authors
Seelig, Eleonora
Henning, Elana
Keogh, Julia M
Shin, Evelyn
Buscombe, John
Publication Date
2022-02Journal Title
Clin Endocrinol (Oxf)
ISSN
0300-0664
Publisher
Wiley
Language
en
Type
Article
This Version
AO
VoR
Metadata
Show full item recordCitation
Seelig, E., Henning, E., Keogh, J. M., Gillett, D., Shin, E., Buscombe, J., van der Klaauw, A. A., & et al. (2022). Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying.. Clin Endocrinol (Oxf) https://doi.org/10.1111/cen.14615
Abstract
OBJECTIVE: People who are severely obese due to melanocortin-4 receptor (MC4R) deficiency experience hyperphagia and impaired fullness after a meal (satiety). Meal-induced satiety is influenced by hormones, such as peptide-YY (PYY), which are released by enteroendocrine cells upon nutrient delivery to the small intestine. DESIGN: We investigated whether gastric emptying and PYY levels are altered in MC4R deficiency. METHODS: Gastric emptying was measured with a gastric scintigraphy protocol using technetium-99m (99 Tcm )-Tin Colloid for 3.5 h in individuals with loss of function MC4R variants and a control group of similar age and weight. In a separate study, we measured plasma PYY levels before and at multiple time points after three standardised meals given to individuals with MC4R deficiency and controls. Fasting PYY (basal secretion) and postprandial PYY levels were measured and the area under the curve and inter-meal peak were calculated. RESULTS: We found that gastric emptying time was significantly delayed and percentage meal retention increased in individuals with MC4R deficiency compared to obese controls. In addition, fasting and mean PYY secretion throughout the day were decreased in MC4R deficiency, whereas postprandial PYY secretion was unaltered. CONCLUSION: Delayed gastric emptying and reduced basal PYY secretion may contribute to impaired satiety in people with obesity due to MC4R deficiency.
Keywords
ORIGINAL ARTICLE, ORIGINAL ARTICLES, gastric emptying, MC4R, obesity, PYY
Sponsorship
Wellcome Trust (098497/Z/12/Z)
Wellcome Trust (203513/Z/16/Z)
Wellcome Trust (208363/Z/17/Z)
Identifiers
cen14615
External DOI: https://doi.org/10.1111/cen.14615
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329847
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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