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dc.contributor.authorGrant, Andrew
dc.date.accessioned2021-10-25T23:30:55Z
dc.date.available2021-10-25T23:30:55Z
dc.date.issued2022-02
dc.identifier.issn0306-5251
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329872
dc.description.abstractThe use of genetic data can be of great benefit in drug development. When analysed with appropriate statistical methods, such resources can be leveraged to identify potential drug targets and inform experimental trials [1]. It has been shown that drug development done with the backing of genetic data is more likely to be successful [2]. Increasingly, pharmacological studies are able to harness the results of genome-wide association studies (GWAS), which test for associations between a phenotype and genetic variation across the entire genome. Such studies are rapidly expanding in terms of both size of samples and range of phenotypes [3]. Although GWAS are able to identify many genetic variants that are associated with a phenotypic trait of interest, they are not able to provide, on their own, evidence as to which of these associations are causal, or by which mechanisms these associations come about. New statistical methodology is being developed which uses genetic data to help to answer these questions.
dc.languageeng
dc.publisherWiley
dc.rightsAll rights reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleIntegration of innovative statistical methods using genetic data provides pharmacological insight and facilitates drug development.
dc.typeArticle
prism.publicationDate2021
prism.publicationNameBr J Clin Pharmacol
dc.identifier.doi10.17863/CAM.77317
dcterms.dateAccepted2021-09-08
rioxxterms.versionofrecord10.1111/bcp.15114
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-11-07
dc.contributor.orcidGrant, Andrew [0000-0001-6422-583X]
dc.identifier.eissn1365-2125
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-11-07
cam.orpheus.successMon Nov 22 07:30:33 GMT 2021 - Embargo updated
cam.orpheus.counter3
rioxxterms.freetoread.startdate2022-11-07


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