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dc.contributor.authorBarron, Sarah
dc.contributor.authorSaez, Janire
dc.contributor.authorOwens, Roisin
dc.date.accessioned2021-10-25T23:31:38Z
dc.date.available2021-10-25T23:31:38Z
dc.date.issued2021-06
dc.identifier.issn2701-0198
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329890
dc.description.abstractRespiratory diseases and lower respiratory tract infections are among the leading cause of death worldwide and, especially given the recent severe acute respiratory syndrome coronavirus-2 pandemic, are of high and prevalent socio-economic importance. In vitro models, which accurately represent the lung microenvironment, are of increasing significance given the ethical concerns around animal work and the lack of translation to human disease, as well as the lengthy time to market and the attrition rates associated with clinical trials. This review gives an overview of the biological and immunological components involved in regulating the respiratory epithelium system in health, disease, and infection. The evolution from 2D to 3D cell biology and to more advanced technological integrated models for studying respiratory host-pathogen interactions are reviewed and provide a reference point for understanding the in vitro modeling requirements. Finally, the current limitations and future perspectives for advancing this field are presented.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimals
dc.subjectHumans
dc.subjectModels, Biological
dc.subjectHost-Pathogen Interactions
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.titleIn Vitro Models for Studying Respiratory Host-Pathogen Interactions.
dc.typeArticle
prism.issueIdentifier6
prism.publicationDate2021
prism.publicationNameAdv Biol (Weinh)
prism.startingPagee2000624
prism.volume5
dc.identifier.doi10.17863/CAM.77335
dcterms.dateAccepted2021-03-11
rioxxterms.versionofrecord10.1002/adbi.202000624
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-06
dc.contributor.orcidBarron, Sarah [0000-0002-9922-2388]
dc.contributor.orcidOwens, Roisin [0000-0001-7856-2108]
dc.identifier.eissn2701-0198
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/L015889/1)
pubs.funder-project-idEPSRC (2108865)
cam.issuedOnline2021-05-04


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International