Show simple item record

dc.contributor.authorXavier, Tania
dc.contributor.authorCondon, Sylvie
dc.contributor.authorPichon, Christophe
dc.contributor.authorLe Gall, Erwan
dc.contributor.authorPresset, Marc
dc.date.accessioned2021-10-26T23:30:29Z
dc.date.available2021-10-26T23:30:29Z
dc.date.issued2021
dc.identifier.issn1860-5397
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329918
dc.description.abstractThe use of mono-substituted malonic acid half oxyesters (SMAHOs) has been hampered by the sporadic references describing their preparation. An evaluation of different approaches has been achieved, allowing to define the best strategies to introduce diversity on both the malonic position and the ester function. A classical alkylation step of a malonate by an alkyl halide followed by a monosaponification gave access to reagents bearing different substituents at the malonic position, including functionalized derivatives. On the other hand, the development of a monoesterification step of a substituted malonic acid derivative proved to be the best entry for diversity at the ester function, rather than the use of an intermediate Meldrum acid. Both these transformations are characterized by their simplicity and efficiency, allowing a straightforward access to SMAHOs from cheap starting materials.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherBeilstein Institut
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titlePreparation of mono-substituted malonic acid half oxyesters (SMAHOs).
dc.typeArticle
prism.endingPage2094
prism.publicationDate2021
prism.publicationNameBeilstein J Org Chem
prism.startingPage2085
prism.volume17
dc.identifier.doi10.17863/CAM.77361
dcterms.dateAccepted2021-08-03
rioxxterms.versionofrecord10.3762/bjoc.17.135
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-01
dc.contributor.orcidXavier, Tania [0000-0003-4306-8040]
dc.contributor.orcidCondon, Sylvie [0000-0002-5366-4893]
dc.contributor.orcidLe Gall, Erwan [0000-0002-8972-3971]
dc.contributor.orcidPresset, Marc [0000-0003-0994-5572]
dc.identifier.eissn1860-5397
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-08-18


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International