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dc.contributor.authorNikolaidis, Marios
dc.contributor.authorMarkoulatos, Panayotis
dc.contributor.authorVan de Peer, Yves
dc.contributor.authorOliver, Stephen
dc.contributor.authorAmoutzias, Grigorios D
dc.date.accessioned2021-10-26T23:31:10Z
dc.date.available2021-10-26T23:31:10Z
dc.date.issued2022-01-07
dc.identifier.issn0737-4038
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329931
dc.description.abstractCoronaviruses (CoVs) have very large RNA viral genomes with a distinct genomic architecture of core and accessory open reading frames (ORFs). It is of utmost importance to understand their patterns and limits of homologous and nonhomologous recombination, because such events may affect the emergence of novel CoV strains, alter their host range, infection rate, tissue tropism pathogenicity, and their ability to escape vaccination programs. Intratypic recombination among closely related CoVs of the same subgenus has often been reported; however, the patterns and limits of genomic exchange between more distantly related CoV lineages (intertypic recombination) need further investigation. Here, we report computational/evolutionary analyses that clearly demonstrate a substantial ability for CoVs of different subgenera to recombine. Furthermore, we show that CoVs can obtain-through nonhomologous recombination-accessory ORFs from core ORFs, exchange accessory ORFs with different CoV genera, with other viruses (i.e., toroviruses, influenza C/D, reoviruses, rotaviruses, astroviruses) and even with hosts. Intriguingly, most of these radical events result from double crossovers surrounding the Spike ORF, thus highlighting both the instability and mobile nature of this genomic region. Although many such events have often occurred during the evolution of various CoVs, the genomic architecture of the relatively young SARS-CoV/SARS-CoV-2 lineage so far appears to be stable.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe Neighborhood of the Spike Gene Is a Hotspot for Modular Intertypic Homologous and Nonhomologous Recombination in Coronavirus Genomes.
dc.typeArticle
prism.publicationDate2021
prism.publicationNameMol Biol Evol
dc.identifier.doi10.17863/CAM.77374
rioxxterms.versionofrecord10.1093/molbev/msab292
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-10-12
dc.contributor.orcidOliver, Stephen [0000-0001-6330-7526]
dc.contributor.orcidAmoutzias, Grigorios D [0000-0001-5961-964X]
dc.identifier.eissn1537-1719
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-10-12
cam.orpheus.success2021-10-26 - Embargo set during processing via Fast-track
rioxxterms.freetoread.startdate2021-10-12


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International